{"created":"2023-05-15T16:41:19.053000+00:00","id":15920,"links":{},"metadata":{"_buckets":{"deposit":"9969b617-000b-4a61-bb3e-6a050dad349b"},"_deposit":{"created_by":2,"id":"15920","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"15920"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00015920","sets":["29:30"]},"author_link":["59521","59522","59527","59528","59530","59526","59529","59524","59531","59525","59523"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"872","bibliographicPageStart":"867","bibliographicVolumeNumber":"67","bibliographic_titles":[{"bibliographic_title":"Annals of the rheumatic diseases"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"OBJECTIVE: To assess the association of CD40/CD40 ligand (CD40L) interactions with the development of skin fibrosis and autoimmunity in tight-skin (TSK/+) mouse, which is a mouse model for human systemic sclerosis. METHODS: Newly born TSK/+ mice were treated with murine anti-CD40L monoclonal antibody (100 microg intraperitoneally weekly). Hypodermal thickness of 8-week-old female mice (defined as the thickness of a subcutaneous loose connective tissue layer beneath the panniculus carnosus) was measured under a light microscope. All skin sections were taken from the para-midline, upper back region. Serum anti-topoisomerase I autoantibody levels, serum immunoglobulin levels and plasma soluble CD40L levels were determined by enzyme-linked immunosorbent assay. For analysis of lymphocyte surface molecules, single cell suspensions of lymphocytes were stained by monoclonal antibodies. Proliferation of TSK/+ B cells and fibroblasts to anti-CD40 antibodies was assessed by the uptake of [3H]-labelled thymidine and bromodeoxyuridine, respectively. RESULTS: The blockade of CD40/CD40L interactions by anti-CD40L monoclonal antibody significantly reduced cutaneous fibrosis (65%) and anti-topoisomerase I autoantibody in TSK/+ mice. Anti-CD40L monoclonal antibody also normalised B lymphocyte abnormal activation in TSK/+ mice, demonstrated by hyper-gamma-globulinaemia. Furthermore, augmented CD40/CD40L interactions in TSK/+ mice were suggested by upregulated expression of CD40L on CD4(+) T cells, elevated plasma soluble CD40L levels. The hyperresponsiveness to CD40 stimulation was also observed in TSK/+ B cells and fibroblasts. CONCLUSIONS: Cutaneous fibrosis and autoimmunity in TSK/+ mice are closely correlated with CD40/CD40L interactions.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Annals of the rheumatic diseases, 67(6), pp.867-872; 2008","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"BMJ Publishing Group"}]},"item_2_relation_11":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"17823201","subitem_relation_type_select":"PMID"}}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1136/ard.2007.073387","subitem_relation_type_select":"DOI"}}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00533085","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00034967","subitem_source_identifier_type":"ISSN"}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"14682060","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Komura, Kazuhiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fujimoto, M"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yanaba, Koichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsushita, Takeji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsushita, Y"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Horikawa, Mayuka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ogawa, Fumihide"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shimizu, K"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hasegawa, M"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takehara, K"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sato, Shinichi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-23"}],"displaytype":"detail","filename":"ARD67_867.pdf","filesize":[{"value":"578.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ARD67_867.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/15920/files/ARD67_867.pdf"},"version_id":"4735a78b-3b9c-43c7-af4e-b3d886c5da36"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Blockade of CD40/CD40 ligand interactions attenuates skin fibrosis and autoimmunity in the tight-skin mouse.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Blockade of CD40/CD40 ligand interactions attenuates skin fibrosis and autoimmunity in the tight-skin mouse."}]},"item_type_id":"2","owner":"2","path":["30"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-09-10"},"publish_date":"2010-09-10","publish_status":"0","recid":"15920","relation_version_is_last":true,"title":["Blockade of CD40/CD40 ligand interactions attenuates skin fibrosis and autoimmunity in the tight-skin mouse."],"weko_creator_id":"2","weko_shared_id":2},"updated":"2023-05-15T19:12:01.909127+00:00"}