@article{oai:nagasaki-u.repo.nii.ac.jp:00016133,
 author = {Nanashima, Atsushi and Shibata, Kenichirou and Nakayama, Toshiyuki and Tobinaga, Syuuichi and Araki, Masato and Kunizaki, Masaki and Takeshita, Hiroaki and Hidaka, Shigekazu and Sawai, Terumitsu and Nagayasu, Takeshi and Yasutake, Toru},
 issue = {8},
 journal = {Annals of surgical oncology},
 month = {Aug},
 note = {BACKGROUND: Microvessel count (MVC) has been correlated with patient prognosis in hepatocellular carcinoma. We investigated whether MVC assessed by staining with CD34 antibody was associated with disease-free and overall survival in patients with metastatic liver cancer (MLC). METHODS: We examined relationships between MVC and clinicopathologic factors or postoperative outcomes in 139 MLC patients who underwent hepatectomy between 1990 and 2006. CD34 expression was analyzed by the immunohistochemical method. RESULTS: MVC was associated with fibrous pseudocapsular formation on histological examination. By means of the modern Japanese classification of liver metastasis, poorer survival was associated with higher score, poorly differentiated adenocarcinoma, higher preoperative carcinoembryonic antigen (CEA) level, fibrous pseudocapsular formation, and smaller surgical margin. Shorter disease-free survival was associated with higher score when the Japanese classification of liver metastasis was used, multiple or bilobar tumor, regional lymph node metastasis in primary colon carcinoma, preoperative CEA level, fibrous pseudocapsular formation, and smaller surgical margin (<5 mm). Higher MVC (>/=406/mm(2)) was associated with decreased disease-free and overall survival by univariate analysis (P = .034 and P = .021, respectively), and higher MVC represented an independently poor prognostic factor in overall survival by Cox multivariate analysis (risk ratio, 2.71; P = .023) in addition to histological differentiation. CONCLUSIONS: Tumor MVC seems to be a useful prognostic marker of MLC patient survival., Annals of Surgical Oncology, 16(8), pp.2130-2137; 2009},
 pages = {2130--2137},
 title = {Clinical Significance of Microvessel Count in Patients with Metastatic Liver Cancer Originating from Colorectal Carcinoma.},
 volume = {16},
 year = {2009}
}