@article{oai:nagasaki-u.repo.nii.ac.jp:00001617,
 author = {Tateishi, Yohei and Kanamoto, Tadashi and Nakaoka, Kenjiro and Yoshimura, Shunsuke and Miyazaki, Teiichiro and Shiraishi, Hirokazu and Morimoto, Shimpei and Tsuneto, Akira and Maemura, Koji and Morofuji, Yoichi and Horie, Nobutaka and Izumo, Tsuyoshi and Tsujino, Akira},
 journal = {Journal of the Neurological Sciences},
 month = {Mar},
 note = {Purpose: The aim of this study was to identify whether diastolic dysfunction predicts death at 90 days after acute ischemic stroke.Methods: We retrospectively analyzed patients with ischemic stroke.
 All patients underwent transthoracic echocardiography to evaluate systolic function and diastolic function
 by means of assessing ejection fraction and septal E/e’.We evaluated the initial National Institute of Health Stroke Scale (NIHSS) score,arterial occlusion, and laboratory data. We used multivariate regression models to identify independent predictors of 90-day mortality. Results: Among 1208 patients, the overall 90-day mortality rate was 8%. In multivariate logistic regression analysis, a higher initial NIHSS score,plasma D-dimer level and E/e’ and occlusion of internal carotid artery or basilar artery were independent predictors of 90-day mortality.The DONE score derived from these valuables showed good discrimination with area under the curve (AUC) value of 0.82 (95% confidence interval [CI],0.78?0.87) to predict 90-day mortality. The DONE score also predicted poor outcome (modified Rankin scale score, 4?6) at 90 days (AUC, 0.82;95% CI 0.80?0.85). Conclusions: Higher E/e’ indicating diastolic dysfunction,may be associated with 90-day mortality in patients with acute ischemic stroke. The DONE score could readily predict poor outcome after acute ischemic stroke., Journal of the Neurological Sciences, 398, pp.157-162; 2019},
 pages = {157--162},
 title = {A score using left ventricular diastolic dysfunction to predict 90-day mortality in acute ischemic stroke: The DONE score},
 volume = {398},
 year = {2019}
}