@article{oai:nagasaki-u.repo.nii.ac.jp:00016172,
 author = {Sugahara, Ikuko and Ando, Takao and Usa, Toshiro and Kawakami, Atsushi and Ashizawa, Kiyoto and Uga, Tatsuya and Maeda, Shigeto and Kanematsu, Takashi and Eguchi, Katsumi},
 issue = {1},
 journal = {Acta medica Nagasakiensia},
 month = {Jul},
 note = {Although the inducible form of cyclooxygenase (COX), COX-2, is highly expressed in various cancers and it is also involved in cancer progression, its role in thyroid cancer is not fully understood. We assessed in the situ cyclooxygenase expression in normal thyroids (n=6), Graves' thyroids (n=6), thyroid adenomas (n=12), thyroid follicular (n=15) and papillary carcinomas (n=30). In comparison to the constitutive expression of COX-1, COX-2 was highly expressed in thyroid cancers (90.0% of thyroid papillary carcinomas and 73.3% of thyroid follicular carcinomas) and moderately in thyroid adenomas (25.5%), but barely expressed in normal and Graves' thyroid tissues. This quantitative assessment employed immunohistochemical methods. Thereafter we compared the effect of COX-2 inhibition on a human follicular thyroid carcinoma cell line (WRO), and a human papillary carcinoma cell line (NPA), using selective COX-2 inhibitor(NS-398). The treatment with 50 μM NS-398 suppressed the growth of the COX-2 expressing cells, NPA cells (37.7%;p<0.01) and WRO cells (10.1%;p<0.05). Moreover, at concentrations ? 100 μM, NS-398 induced cell death a mitochondrial dysfunction. In addition, 50 μM of NS-398 inhibited the activation of extracellular signal-regulated kinase in NPA cells after the stimulation with fetal bovine serum. Our results indicate that COX-2 is involved in the progression of thyroid cancer., Acta medica Nagasakiensia, 54(1), pp.9-14 ; 2009},
 pages = {9--14},
 title = {Cyclooxygenase-2 is Involved in the Progression of Thyroid Cancer},
 volume = {54},
 year = {2009}
}