@article{oai:nagasaki-u.repo.nii.ac.jp:00016201,
 author = {Yanagihara, Katsunori and Kihara, Rie and Araki, Nobuko and Morinaga, Yoshitomo and Seki, Masafumi and Izumikawa, Koichi and Kakeya, Hiroshi and Yamamoto, Yoshihiro and Yamada, Yasuaki and Kohno, Shigeru and Tsukamoto, Kazuhiro and Kamihira, Shimeru},
 issue = {5},
 journal = {International journal of antimicrobial agents},
 month = {Nov},
 note = {Many strains of community-acquired meticillin-resistant Staphylococcus aureus (MRSA) have a pore-forming leukotoxin, known as Panton-Valentine leukocidin (PVL), which can cause severe necrotising pneumonia. Linezolid (LZD) is a new antibacterial agent with potent antibacterial activity against MRSA. In this study, a mouse model of haematogenous pulmonary infection was used to compare the efficacies of LZD and vancomycin (VAN) against pulmonary infection caused by PVL-positive S. aureus. Following antibiotic administration for 3 days, the number of viable bacteria (mean+/-standard error of the mean) in the control, VAN and LZD groups was 6.77+/-0.14, 5.29+/-0.27 and 4.25+/-0.33log colony-forming units/lung, respectively. LZD significantly decreased the number of viable bacteria in the lungs compared with the control and VAN groups (P<0.05). The survival rate at Day 7 post-inoculation was higher in the LZD group (100%) than in the VAN group (50%) or the control group (0%). Histopathological examination and cytokine analysis also showed the beneficial efficacy of LZD compared with VAN. In conclusion, LZD significantly reduced bacterial numbers and inflammation in a mouse model of PVL-positive S. aureus haematogenous infection and improved the survival rate of infected mice compared with VAN. LZD is clinically effective against PVL-positive S. aureus., International journal of antimicrobial agents, 34(5), pp.477-481; 2009},
 pages = {477--481},
 title = {Efficacy of linezolid against Panton-Valentine leukocidin (PVL)-positive meticillin-resistant Staphylococcus aureus (MRSA) in a mouse model of haematogenous pulmonary infection.},
 volume = {34},
 year = {2009}
}