{"created":"2023-05-15T16:41:34.921335+00:00","id":16254,"links":{},"metadata":{"_buckets":{"deposit":"112e6315-71b2-4a6c-8440-05e5f901bb64"},"_deposit":{"created_by":2,"id":"16254","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"16254"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00016254","sets":["50:51"]},"author_link":["61233","61235","61236","61234","61232","61237","61231","61238"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"389","bibliographicPageStart":"386","bibliographicVolumeNumber":"27","bibliographic_titles":[{"bibliographic_title":"Fish & shellfish immunology"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We previously reported that high virulent strain (NUF251) of Edwardsiella tarda has an ability to prevent the production of reactive oxygen species by macrophages, and is even capable of surviving and multiplying within Japanese flounder (Paralichthys olivaceus) peritoneal macrophages, whereas the low virulent strain (NUF194) has no such ability. In this study, we found that NUF251 and NUF194 induced NO and TNF-alpha production from Japanese flounder peritoneal macrophages, and NUF251 caused faster induction of NO release and much higher level of TNF-alpha production than NUF194. In addition, similar differences between two strains in terms of the induction of NO and TNF-alpha production were also observed in mouse macrophage cell line RAW264.7 cells. Our results suggest that the potent ability to induce the production of NO and TNF-alpha from macrophages may be one of the factors responsible for the virulence of E. tarda.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Fish & shellfish immunology, 27(2), pp.386-389; 2009","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier Ltd"}]},"item_2_relation_11":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"19539031","subitem_relation_type_select":"PMID"}}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.fsi.2009.06.002","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright c 2009 Elsevier Ltd All rights reserved."}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA10838941","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"10504648","subitem_source_identifier_type":"ISSN"}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"1095-9947","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ishibe, Keiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamanishi, Tomohiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Wang, Yajun"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Osatomi, Kiyoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hara, Kenji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kanai, Kinya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamaguchi, Kenichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Oda, Tatsuya"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-23"}],"displaytype":"detail","filename":"FSI27_386.pdf","filesize":[{"value":"158.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"FSI27_386.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/16254/files/FSI27_386.pdf"},"version_id":"eebff773-a059-49fe-9375-d41f800e0b17"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Edwardsiella tarda","subitem_subject_scheme":"Other"},{"subitem_subject":"Bacterial infection","subitem_subject_scheme":"Other"},{"subitem_subject":"Japanese flounder","subitem_subject_scheme":"Other"},{"subitem_subject":"Macrophage","subitem_subject_scheme":"Other"},{"subitem_subject":"Mouse macrophage cell line","subitem_subject_scheme":"Other"},{"subitem_subject":"Nitric oxide","subitem_subject_scheme":"Other"},{"subitem_subject":"Tumor necrosis factor-α","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Comparative analysis of the production of nitric oxide (NO) and tumor necrosis factor-alpha (TNF-alpha) from macrophages exposed to high virulent and low virulent strains of Edwardsiella tarda.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Comparative analysis of the production of nitric oxide (NO) and tumor necrosis factor-alpha (TNF-alpha) from macrophages exposed to high virulent and low virulent strains of Edwardsiella tarda."}]},"item_type_id":"2","owner":"2","path":["51"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-09-07"},"publish_date":"2009-09-07","publish_status":"0","recid":"16254","relation_version_is_last":true,"title":["Comparative analysis of the production of nitric oxide (NO) and tumor necrosis factor-alpha (TNF-alpha) from macrophages exposed to high virulent and low virulent strains of Edwardsiella tarda."],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-17T20:51:53.335480+00:00"}