{"created":"2023-05-15T16:30:29.067940+00:00","id":1629,"links":{},"metadata":{"_buckets":{"deposit":"73d1e94d-164b-4a8d-9a4d-b767062a60dd"},"_deposit":{"created_by":2,"id":"1629","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"1629"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00001629","sets":["10:11"]},"author_link":["7886","7885","7884","7880","7875","7871","7877","7879","7872","7870","7874","7876","7881","7883","7882","7888","7878","7889","7887","7873"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-03-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"1294","bibliographicPageStart":"1278","bibliographicVolumeNumber":"129","bibliographic_titles":[{"bibliographic_title":"Journal of Clinical Investigation"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Immune checkpoint inhibitors and adoptive transfer of gene-engineered T cells have emerged as novel therapeutic modalities for hard-to-treat solid tumors; however, many patients are refractory to these immunotherapies, and the mechanisms \nunderlying tumor immune resistance have not been fully elucidated. By comparing the tumor microenvironment of checkpoint inhibition-sensitive and -resistant murine solid tumors, we observed that the resistant tumors had low immunogenicity. We identified antigen presentation by CD11b+F4/80+ tumor-associated macrophages (TAMs) as a key factor correlated with immune resistance. In the resistant tumors, TAMs remained inactive and did not exert antigen-presenting activity. Targeted delivery of a long peptide antigen to TAMs by using a nano-sized hydrogel (nanogel) in the presence of a TLR agonist activated TAMs, induced their antigen-presenting activity, and thereby transformed the resistant tumors into tumors sensitive to adaptive immune responses such as adoptive transfer of tumor-specific T cell receptor-engineered T cells. \nThese results indicate that the status and function of TAMs have a significant impact on tumor immune sensitivity and that manipulation of TAM functions would be an effective approach for improving the efficacy of immunotherapies.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"The Journal of clinical investigation, 129(3), pp.1278-1294; 2019","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"American Society for Clinical Investigation"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1172/JCI97642","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c 2019, American Society for Clinical Investigation."}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00219738","subitem_source_identifier_type":"ISSN"}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"15588238","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Muraoka, Daisuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Seo, Naohiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hayashi, Tae"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tahara, Yoshiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fujii, Keisuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tawara, Isao"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miyahara, Yoshihiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Okamori, Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yagita, Hideo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Imoto, Seiya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamaguchi, Rui"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Komura, Mitsuhiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miyano, Satoru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Goto, Masahiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sawada, Shin-ichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Asai, Akira"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ikeda, Hiroaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Akiyoshi, Kazunari"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Harada, Naozumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shiku, Hiroshi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-18"}],"displaytype":"detail","filename":"JCI129_1278.pdf","filesize":[{"value":"7.3 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"JCI129_1278.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/1629/files/JCI129_1278.pdf"},"version_id":"8ccb098e-8afa-402c-b0c3-0b19d694c99f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Cancer immunotherapy","subitem_subject_scheme":"Other"},{"subitem_subject":"Immunology","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Antigen delivery targeted to tumor-associated macrophages overcomes tumor immune resistance","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Antigen delivery targeted to tumor-associated macrophages overcomes tumor immune resistance"}]},"item_type_id":"2","owner":"2","path":["11"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-03-26"},"publish_date":"2019-03-26","publish_status":"0","recid":"1629","relation_version_is_last":true,"title":["Antigen delivery targeted to tumor-associated macrophages overcomes tumor immune resistance"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T03:59:03.951578+00:00"}