@article{oai:nagasaki-u.repo.nii.ac.jp:00001630,
 author = {Sakashita, Kentaro and Murata, Kengo and Takahashi, Yukiko and Yamamoto, Miake and Oohashi, Kana and Sato, Yu and Kitazono, Miyako and Wada, Akihiko and Takamori, Mikio},
 issue = {4},
 journal = {Internal Medicine},
 month = {Feb},
 note = {Objective The standard anti-tuberculosis (TB) regimen occasionally causes acute kidney injury (AKI). The major etiology is rifampicin-induced acute interstitial nephritis. However, the standard management 
of AKI induced by anti-TB drugs has yet to be established. Methods We retrospectively reviewed patients with TB who developed AKI after starting standard anti-TB treatment between 2006 and 2016 at a single TB center. 
The clinical characteristics and the management are described. Results Among 1,430 patients with active TB, 15 (1.01%) developed AKI. The mean age (standard devia-tion) was 61 years (18). The median (interquartile range) time to AKI development was 45 days (21-54 days). The median serum creatinine level before anti-TB treatment was 0.7 mg/dL (0.5-1.4 mg/dL), whereas the median peak serum creatinine level after AKI onset was 4.0 mg/dL (3.08-5.12 mg/dL). Five patients (33.3%) were pathologically confirmed as having acute interstitial nephritis (AIN), and 7 patients (46.7%) had a clinical diagnosis of the disease. All anti-TB drugs were stopped, 
and steroids were administered to 5 (100%) patients with pathologically confirmed AIN and 3 (42.8%) patients with clinically diagnosed AIN. The renal function was normalized in 12 patients (80.0%) after restarting anti-TB treatment without rifampicin (n=12) or isoniazid (n=1). 
Two patients died due to severe renal failure after restarting rifampicin. 
Conclusion Rifampicin is the leading cause of AKI. Levofloxacin may be an alternative to rifampicin thanks to its safety and potency. Restarting anti-TB treatment without rifampicin and short-term steroid administration may be a feasible management for AKI., Internal Medicine, 58(4), pp.521-527; 2019},
 pages = {521--527},
 title = {A Case Series of Acute Kidney Injury During Anti-tuberculosis Treatment},
 volume = {58},
 year = {2019}
}