{"created":"2023-05-15T16:41:36.933057+00:00","id":16301,"links":{},"metadata":{"_buckets":{"deposit":"1cc534c5-5f1f-47a8-9bd5-c383c4245e72"},"_deposit":{"created_by":2,"id":"16301","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"16301"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00016301","sets":["29:30"]},"author_link":["61508","61507","61506"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-07","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"7","bibliographicPageEnd":"917","bibliographicPageStart":"907","bibliographicVolumeNumber":"19","bibliographic_titles":[{"bibliographic_title":"Expert opinion on therapeutic patents"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"BACKGROUND: There has been a dramatic decrease in the risk of transmission of bovine spongiform encephalopathy to humans. In contrast, the risk of human-to-human transmission of variant Creutzfeldt-Jakob disease (vCJD) via medical treatments became potentially high since 4 vCJD cases were reported to be possibly transmitted through blood transfusion in the UK. However, no treatments are yet available for curing prion diseases. OBJECTIVE: Conversion of the normal prion protein, PrP(C), to the amyloidogenic PrP, PrP(Sc), plays a pivotal role in the pathogenesis. Recently, certain anti-PrP or anti-37/67-kDa laminin receptor (LRP/LR) antibodies were shown to have the potential to cure chronically infected cells, clearing PrP(Sc) from the cells. This has raised the possibility of antibody based-immunotherapy for prion diseases. This article aims to introduce and discuss the recently published attempts of immunotherapy in prion diseases. METHODS: Bibliographic research was carried out using the PubMed database. Patent literature was searched using the UK Intellectual Property Office website. RESULTS/CONCLUSION: No satisfying consequences in animals could be detected with anti-PrP antibodies directly infused into the brains of animals by the intraventricular route or by anti-PrP or anti-LRP/LR single chain fragment antibodies directly delivered into the brain by virus vector-mediated gene transfer. This is probably because such delivery systems failed to deliver the antibodies to the neurons relevant for the treatments.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Expert opinion on therapeutic patents, 19(7), pp.907-917; 2009","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Informa Healthcare"}]},"item_2_relation_11":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"19514955","subitem_relation_type_select":"PMID"}}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1517/13543770902988530","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c 2009 Informa UK Ltd. All rights reserved."},{"subitem_rights":"This is an electronic version of an article published in Expert opinion on therapeutic patents, 19(7), pp.907-917; 2009. Expert opinion on therapeutic patents is available online at: http://www.informaworld.com with the open URL of your article (http://informahealthcare.com/doi/abs/10.1517/13543770902988530)."}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA10996647","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"13543776","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Sakaguchi, Suehiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ishibashi, Daisuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsuda, Haruo"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-23"}],"displaytype":"detail","filename":"EOTP19_907.pdf","filesize":[{"value":"132.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"EOTP19_907.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/16301/files/EOTP19_907.pdf"},"version_id":"e58173b2-b3a5-47e7-a1db-0208ce3a2728"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Antibody","subitem_subject_scheme":"Other"},{"subitem_subject":"Immunotherapy","subitem_subject_scheme":"Other"},{"subitem_subject":"Prion","subitem_subject_scheme":"Other"},{"subitem_subject":"Prion diseases","subitem_subject_scheme":"Other"},{"subitem_subject":"Prion protein","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Antibody-based immunotherapeutic attempts in experimental animal models of prion diseases.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Antibody-based immunotherapeutic attempts in experimental animal models of prion diseases."}]},"item_type_id":"2","owner":"2","path":["30"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-08-02"},"publish_date":"2010-08-02","publish_status":"0","recid":"16301","relation_version_is_last":true,"title":["Antibody-based immunotherapeutic attempts in experimental animal models of prion diseases."],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-17T20:50:10.511535+00:00"}