{"created":"2023-05-15T16:41:38.336214+00:00","id":16334,"links":{},"metadata":{"_buckets":{"deposit":"cb9fcf1b-aec0-4b76-8046-2c0c9b0e6610"},"_deposit":{"created_by":2,"id":"16334","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"16334"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00016334","sets":["27:28"]},"author_link":["61701","61702","61700","61699"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"512","bibliographicPageStart":"503","bibliographicVolumeNumber":"29","bibliographic_titles":[{"bibliographic_title":"Cellular and molecular neurobiology"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"A gap junction blocker, 18beta-glycyrrhetinic acid (beta-GA), increased the membrane resistance of Ia, Ib and II/III cells of frog taste disk by 50, 160, and 300 M Omega, respectively, by blocking the gap junction channels and hemichannels. The amplitudes of gustatory depolarizing potentials in the disk cells for 4 basic taste stimuli were reduced to 40-60% after intravenous injection of beta-GA at 1.0 mg/kg. beta-GA of 1.0 mg/kg did not affect the resting potentials and the reversal potentials for tastant-induced depolarizing potentials in any taste disk cells. The percentage of cells responding to each of 4 basic taste stimuli and varying numbers of 4 taste qualities did not differ between control and beta-GA-treated taste disk cells. This implies that gustatory depolarizing response profiles for 4 basic taste stimuli were very similar in control and beta-GA-treated taste disk cells. It is concluded that beta-GA at 1.0 mg/kg reduced the amplitude of gustatory depolarizing potentials in taste disk cells by strongly blocking depolarizing currents flowing through the gap junction channels and hemichannels, but probably weakly affected the gustatory transduction mechanisms for 4 taste stimuli.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Cellular and molecular neurobiology, 29(4), pp.503-512; 2009","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Netherlands"}]},"item_2_relation_11":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"19145483","subitem_relation_type_select":"PMID"}}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1007/s10571-008-9342-6","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c 2009 Springer Science+Business Media, LLC."},{"subitem_rights":"The original publication is available at www.springerlink.com"}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA10622352","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"02724340","subitem_source_identifier_type":"ISSN"}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"1573-6830","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Sato, Toshihide"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nishishita, Kazuhisa"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Okada, Yukio"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Toda, Kazuo"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-23"}],"displaytype":"detail","filename":"CMN29_503.pdf","filesize":[{"value":"745.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"CMN29_503.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/16334/files/CMN29_503.pdf"},"version_id":"51004903-c38c-4833-8e9d-ab355072f895"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Depolarizing response profile","subitem_subject_scheme":"Other"},{"subitem_subject":"Frog taste disk cell","subitem_subject_scheme":"Other"},{"subitem_subject":"Gap junction blocker","subitem_subject_scheme":"Other"},{"subitem_subject":"Gap junction hemichannel","subitem_subject_scheme":"Other"},{"subitem_subject":"Membrane resistance increase","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Effect of gap junction blocker beta-glycyrrhetinic acid on taste disk cells in frog.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effect of gap junction blocker beta-glycyrrhetinic acid on taste disk cells in frog."}]},"item_type_id":"2","owner":"2","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-10-05"},"publish_date":"2009-10-05","publish_status":"0","recid":"16334","relation_version_is_last":true,"title":["Effect of gap junction blocker beta-glycyrrhetinic acid on taste disk cells in frog."],"weko_creator_id":"2","weko_shared_id":2},"updated":"2023-05-15T18:57:40.183474+00:00"}