{"created":"2023-05-15T16:41:40.141981+00:00","id":16376,"links":{},"metadata":{"_buckets":{"deposit":"4288e07e-ff84-41d1-b141-a35b3de9f45e"},"_deposit":{"created_by":2,"id":"16376","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"16376"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00016376","sets":["35:36"]},"author_link":["61985","61987","61983","61986","61981","61980","61979","61982","61984"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-11-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"234","bibliographicPageStart":"227","bibliographicVolumeNumber":"394","bibliographic_titles":[{"bibliographic_title":"Virology"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Recently it has been reported that a cathepsin B inhibitor, CA-074Me, attenuates ecotropic murine leukemia virus (Eco-MLV) infection in NIH3T3 cells, suggesting that cathepsin B is required for the Eco-MLV infection. However, cathepsin B activity was negative or extremely low in NIH3T3 cells. How did CA-074Me attenuate the Eco-MLV infection? The CA-074Me treatment of NIH3T3 cells inhibited cathepsin L activity, and a cathepsin L specific inhibitor, CLIK148, attenuated the Eco-MLV vector infection. These results indicate that the suppression of cathepsin L activity by CA-074Me induces the inhibition of Eco-MLV infection, suggesting that cathepsin L is required for the Eco-MLV infection in NIH3T3 cells. The CA-074Me treatment inhibited the Eco-MLV infection in human cells expressing the exogenous mouse ecotropic receptor and endogenous cathepsins B and L, but the CLIK148 treatment did not, showing that only the cathepsin L suppression by CLIK148 is not enough to prevent the Eco-MLV infection in cells expressing both of cathepsins B and L, and CA-074Me inhibits the Eco-MLV infection by suppressing both of cathepsins B and L. These results suggest that either cathepsin B or L is sufficient for the Eco-MLV infection.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Virology, 394(2), pp.227-234; 2009","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier"}]},"item_2_relation_11":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"19781728","subitem_relation_type_select":"PMID"}}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.virol.2009.08.045","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright c 2009 Elsevier Inc. All rights reserved."}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00884454","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00426822","subitem_source_identifier_type":"ISSN"}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"10960341","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yoshii, Hiroaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kamiyama, Haruka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Minematsu, Kazuo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Goto, Kensuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mizota, Tsutomu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Oishi, Kazunori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Katunuma, Nobuhiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamamoto, Naoki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kubo, Yoshinao"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-23"}],"displaytype":"detail","filename":"Virology_Kubo.pdf","filesize":[{"value":"955.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Virology_Kubo.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/16376/files/Virology_Kubo.pdf"},"version_id":"a63a1f92-57dd-44ee-a5df-8c45374ac143"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Cathepsin B","subitem_subject_scheme":"Other"},{"subitem_subject":"Cathepsin L","subitem_subject_scheme":"Other"},{"subitem_subject":"Ecotropic murine leukemia virus","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Cathepsin L is required for ecotropic murine leukemia virus infection in NIH3T3 cells.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Cathepsin L is required for ecotropic murine leukemia virus infection in NIH3T3 cells."}]},"item_type_id":"2","owner":"2","path":["36"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-10-16"},"publish_date":"2009-10-16","publish_status":"0","recid":"16376","relation_version_is_last":true,"title":["Cathepsin L is required for ecotropic murine leukemia virus infection in NIH3T3 cells."],"weko_creator_id":"2","weko_shared_id":2},"updated":"2023-05-15T19:23:56.277522+00:00"}