@article{oai:nagasaki-u.repo.nii.ac.jp:00016415,
 author = {Kanda, Shigeru and Kanetake, Hiroshi and Miyata, Yasuyoshi},
 issue = {3},
 journal = {Journal of cellular and molecular medicine},
 month = {May},
 note = {The aim of this study was to determine whether the downregulation of endogenous Fes by siRNA in cultured endothelial cells affects vascular endothelial growth factor-A (VEGF-A)-induced chemotaxis and capillary-like morphogenesis, which are considered as angiogenic cellular responses in vitro. VEGF-A-treatment induced autophosphorylation of Fes in cultured endothelial cells. LY294002, a phosphoinositide 3-kinase inhibitor, significantly inhibited VEGF-A-induced chemotaxis and capillary-like morphogenesis. Downregulation of Fes attenuated these VEGF-A-induced cellular responses but LY294002 did not produce further inhibition of these responses. Downregulation of Fes neither affected VEGF-A-induced autophosphorylation of VEGF receptor 2 nor mitogen-activated protein kinase activation, but markedly decreased Akt activation. Taken together, our novel results indicate the involvement of Fes in VEGF-A-induced cellular responses by cultured endothelial cells., Journal of cellular and molecular medicine, 11(3), pp.495-501; 2007},
 pages = {495--501},
 title = {Downregulation of Fes inhibits VEGF-A-induced chemotaxis and capillary-like morphogenesis by cultured endothelial cells.},
 volume = {11},
 year = {2007}
}