@article{oai:nagasaki-u.repo.nii.ac.jp:00016432,
 author = {Tsukuba, Takayuki and Yanagawa, Michiyo and Okamoto, Kuniaki and Okamoto, Yoshiko and Yasuda, Yoshiyuki and Nakayama, Keiichi I and Kadowaki, Tomoko and Yamamoto, Kenji},
 issue = {5},
 journal = {Journal of biochemistry},
 month = {May},
 note = {Cathepsin E is an endo-lysosomal aspartic proteinase exclusively present in immune system cells. Previous studies have shown that cathepsin E-deficient (CatE(-/-)) mice display aberrant immune responses such as atopic dermatitis and higher susceptibility to bacterial infection. However, the mechanisms underlying abnormal immune responses induced by cathepsin E deficiency are still unclear. In this study, we found that the cell-surface levels of chemotactic receptors, including chemokine receptor (CCR)-2 and N-formyl peptide receptors (FPRs), were clearly diminished in CatE(-/-)macrophages compared with those in wild-type cells. Consistently, chemotaxis of CatE(-/-)macrophages to MCP-1 and N-formyl-methionyl-leucyl-phenylalanine was also decreased. Similar to the chemotactic receptors, the surface expressions of the adhesion receptors CD18 (integrin beta(2)) and CD 29 (integrin beta(1)) in CatE(-/-) macrophages were significantly decreased, thereby reducing cell attachment of CatE(-/-) macrophages. These results indicate that the defects in chemotaxis and cell adhesion are likely to be involved in the imperfect function of CatE(-/-)macrophages., Journal of biochemistry, 145(5), pp.565-573; 2009},
 pages = {565--573},
 title = {Impaired chemotaxis and cell adhesion due to decrease in several cell-surface receptors in cathepsin E-deficient macrophages.},
 volume = {145},
 year = {2009}
}