{"created":"2023-05-15T16:41:42.551087+00:00","id":16432,"links":{},"metadata":{"_buckets":{"deposit":"fe399467-a141-4b9d-b2f4-afe7038462a4"},"_deposit":{"created_by":2,"id":"16432","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"16432"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00016432","sets":["27:28"]},"author_link":["62290","62285","62291","62286","62289","62288","62287","62284"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-05","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"573","bibliographicPageStart":"565","bibliographicVolumeNumber":"145","bibliographic_titles":[{"bibliographic_title":"Journal of biochemistry"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Cathepsin E is an endo-lysosomal aspartic proteinase exclusively present in immune system cells. Previous studies have shown that cathepsin E-deficient (CatE(-/-)) mice display aberrant immune responses such as atopic dermatitis and higher susceptibility to bacterial infection. However, the mechanisms underlying abnormal immune responses induced by cathepsin E deficiency are still unclear. In this study, we found that the cell-surface levels of chemotactic receptors, including chemokine receptor (CCR)-2 and N-formyl peptide receptors (FPRs), were clearly diminished in CatE(-/-)macrophages compared with those in wild-type cells. Consistently, chemotaxis of CatE(-/-)macrophages to MCP-1 and N-formyl-methionyl-leucyl-phenylalanine was also decreased. Similar to the chemotactic receptors, the surface expressions of the adhesion receptors CD18 (integrin beta(2)) and CD 29 (integrin beta(1)) in CatE(-/-) macrophages were significantly decreased, thereby reducing cell attachment of CatE(-/-) macrophages. These results indicate that the defects in chemotaxis and cell adhesion are likely to be involved in the imperfect function of CatE(-/-)macrophages.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Journal of biochemistry, 145(5), pp.565-573; 2009","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"The Japanese Biochemical Society"}]},"item_2_relation_11":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"19174547","subitem_relation_type_select":"PMID"}}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1093/jb/mvp016","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c The Authors 2009. Published by Oxford University Press on behalf of the Japanese Biochemical Society. All rights reserved"}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00694073","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0021924X","subitem_source_identifier_type":"ISSN"}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"1756-2651","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Tsukuba, Takayuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yanagawa, Michiyo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Okamoto, Kuniaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Okamoto, Yoshiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yasuda, Yoshiyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakayama, Keiichi I"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kadowaki, Tomoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamamoto, Kenji"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-23"}],"displaytype":"detail","filename":"JouBio145_565.pdf","filesize":[{"value":"327.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"JouBio145_565.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/16432/files/JouBio145_565.pdf"},"version_id":"b25a064a-8e05-4435-b3bd-57aaea24932a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Aspartic proteinase","subitem_subject_scheme":"Other"},{"subitem_subject":"Cathepsin E","subitem_subject_scheme":"Other"},{"subitem_subject":"Cell adhesion","subitem_subject_scheme":"Other"},{"subitem_subject":"Chemotaxis","subitem_subject_scheme":"Other"},{"subitem_subject":"Knockout","subitem_subject_scheme":"Other"},{"subitem_subject":"Macrophages","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Impaired chemotaxis and cell adhesion due to decrease in several cell-surface receptors in cathepsin E-deficient macrophages.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Impaired chemotaxis and cell adhesion due to decrease in several cell-surface receptors in cathepsin E-deficient macrophages."}]},"item_type_id":"2","owner":"2","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-11-02"},"publish_date":"2009-11-02","publish_status":"0","recid":"16432","relation_version_is_last":true,"title":["Impaired chemotaxis and cell adhesion due to decrease in several cell-surface receptors in cathepsin E-deficient macrophages."],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-17T20:47:19.918000+00:00"}