@article{oai:nagasaki-u.repo.nii.ac.jp:00016463,
 author = {Hirakawa, Hiroshi and Nakayama, Toshiyuki and Shibata, Kenichiro and Sekine, Ichiro},
 issue = {3},
 journal = {Oncology Reports},
 month = {Sep},
 note = {Glycogen synthase kinase 3beta (GSK-3beta) is a multifunctional serine/threonine kinase involved in several signaling pathways. Recently, we reported the polarized localization of GSK-3beta on the apical membrane of normal colon epithelium. To investigate the functions of this molecule, we studied stomach and colorectal cancer tissues. In normal simple columnar epithelium, GSK-3beta was localized with tight junction-associated protein ZO-1 in a single line at the apical cell border. GSK-3beta and ZO-1 were localized in the apical regions of tubular adenocarcinoma, similar to their localization in normal epithelium; however, their localization was different at the invasive front of the cancer and was found to be associated with lymphatic invasion. In signet-ring cell carcinoma of the stomach, the expression of these proteins was reduced and dot-like expression was observed in each cell of the signet-ring cell carcinoma. We speculated that GSK-3beta is involved in glandular structure formation and that the non-apical localization of membrane-localized GSK-3beta in tubular adenocarcinoma is associated with cancer development., Oncology Reports, 22(3), pp.481-485; 2009},
 pages = {481--485},
 title = {Association of cellular localization of glycogen synthase kinase 3beta in the digestive tract with cancer development.},
 volume = {22},
 year = {2009}
}