{"created":"2023-05-15T16:41:44.530353+00:00","id":16478,"links":{},"metadata":{"_buckets":{"deposit":"d058772c-5971-46fc-b01c-af7fdb058ece"},"_deposit":{"created_by":2,"id":"16478","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"16478"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00016478","sets":["29:30"]},"author_link":["62615","62614","62617","62613","62616","62612","62611"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"10","bibliographicPageEnd":"652","bibliographicPageStart":"646","bibliographicVolumeNumber":"44","bibliographic_titles":[{"bibliographic_title":"Experimental gerontology"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Calorie restriction (CR) and a reduced growth hormone (GH) signal affect insulin sensitivity and lifespan in mammals in a similar manner. We investigated the effects of CR and moderate inhibition of GH on glucose-stimulated activation of insulin signaling and the expression of genes related to fat metabolism in white adipose tissue (WAT) in rats. We used 10-month-old male, wild-type (W) Wistar rats, fed ad libitum (AL) or a 30% CR diet from 6weeks of age, and transgenic (Tg) rats with moderately suppressed GH signaling. Rats were killed 15min after an intraperitoneal injection of glucose or saline. In control W-AL rats, the levels of serum insulin, phosphorylated (p) insulin receptor (pY-IR), p-Akt, and the expression of glucose transporter (Glut) 4 in the membrane fraction were greater in the glucose-injected group than in the saline-injected group, indicating significant activation of insulin signaling in response to glucose loading. In the W-CR and Tg-AL rats, the serum insulin and pY-IR levels were lower than those in the W-AL rats. The Akt-Glut pathway was up-regulated even after saline-injection. Expression levels of adipogenic and lipogenic genes including PPARgamma, adiponectin, and its receptors, were higher in the W-CR rats than in the W-AL and Tg-AL rats. The present findings indicate adipose tissue metabolic profiles specific to CR.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Experimental gerontology, 44(10), pp.646-652; 2009","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier Inc."}]},"item_2_relation_11":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"19646410","subitem_relation_type_select":"PMID"}}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.exger.2009.07.002","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright c 2009 Elsevier Inc. All rights reserved."}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00641077","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"05315565","subitem_source_identifier_type":"ISSN"}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"1873-6815","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Park, Seongjoon"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Komatsu, Toshimitsu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hayashi, Hiroko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Trindade, Lucas Siqueira"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamaza, Haruyoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Chiba, Takuya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shimokawa, Isao"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-23"}],"displaytype":"detail","filename":"ExpGer44_646.pdf","filesize":[{"value":"340.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ExpGer44_646.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/16478/files/ExpGer44_646.pdf"},"version_id":"d394f346-88c4-44e1-8e6a-cf0754685049"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Adipose tissue","subitem_subject_scheme":"Other"},{"subitem_subject":"Calorie restriction","subitem_subject_scheme":"Other"},{"subitem_subject":"Glucose uptake","subitem_subject_scheme":"Other"},{"subitem_subject":"Growth hormone","subitem_subject_scheme":"Other"},{"subitem_subject":"Insulin signal","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Divergent regulation of adipose tissue metabolism by calorie restriction and inhibition of growth hormone signaling.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Divergent regulation of adipose tissue metabolism by calorie restriction and inhibition of growth hormone signaling."}]},"item_type_id":"2","owner":"2","path":["30"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-11-17"},"publish_date":"2009-11-17","publish_status":"0","recid":"16478","relation_version_is_last":true,"title":["Divergent regulation of adipose tissue metabolism by calorie restriction and inhibition of growth hormone signaling."],"weko_creator_id":"2","weko_shared_id":2},"updated":"2023-05-15T19:04:40.086097+00:00"}