@article{oai:nagasaki-u.repo.nii.ac.jp:00016527,
 author = {Katsumata, Tatsuya and Kohno, Shigeru and Koga, Hironobu and Yoshitomi, Yuko and Matsuda, Haruko and Mitsutake, Kotaro and Higashiyama, Yasuhito and Miyazaki, Yoshitsugu and Hara, Kohei},
 issue = {4},
 journal = {日本熱帯医学会雑誌, Japanese journal of tropical medicine and hygiene},
 month = {Dec},
 note = {AIDS以外の免疫抑制状態に，ニューモシスチスカリニ肺炎を発症した，10症例に臨床的検討を加えた。発症様式では，成人T細胞白血病の2例は前駆症状が長かったが，他の症例では急性の発症を示した。発症時の胸部レントゲンでは，全例において両側ぴまん性の陰影を認めた。確定診断は，8例において経気管支的肺生検，または気管支肺胞洗浄によって2例において剖検によってなされた。診断時には，LDHの値は発症前の値に比べて高度に上昇しており，肺胞気動脈血酸素分圧較差も高度に開大しており，これらの値が早期診断に有用であることが示唆された。他の日和見感染の合併は，5例に認められた。治療においては，ぺンタミジンとST合剤の併用は，副作用は少なかったものの，有効率も低かった。コルチコステロイドは，補助療法として有用と考えられた。, Ten non-AIDS patients with Pneumocystis carinii pneumonia were studied. While the 2 patients with adult T cell leukemia had longer prodromes, the other 8 patients had acute onset. At presentation a chest radiograph revealed an abnormal bilateral diffuse shadow in all cases. In 8 patients, diagnostic material was obtained by transbronchial lung biopsy and/or bronchoalveolar lavage, and in 2 patients at postmortem. At the time of diagnosis the serum lactate dehydrogenase value was much higher than prior to the acute illness, and the AaDO2 gradient was highly increased: These appear to be useful as markers for an initial diagnosis. Other opportunistic organisms were isolated in 5 patients. The concomitant use of pentamidine and cotrimoxazole was relatively well tolerated, but with a high incidence of treatment failure. Corticosteroids appeared to be effective as an adjunctive therapy., 日本熱帯医学会雑誌, vol.19(4), pp.347-355; 1991},
 pages = {347--355},
 title = {Management of Pneumocystis carinii pneumonia in patients with conventionally caused immune suppression},
 volume = {19},
 year = {1991}
}