{"created":"2023-05-15T16:41:50.410051+00:00","id":16615,"links":{},"metadata":{"_buckets":{"deposit":"f054fc86-ae05-472a-8e7a-f80a7458b5d4"},"_deposit":{"created_by":2,"id":"16615","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"16615"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00016615","sets":["29:30"]},"author_link":["63698","63695","63692","63699","63694","63696","63691","63697","63693"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-11","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"402","bibliographicPageStart":"398","bibliographicVolumeNumber":"76","bibliographic_titles":[{"bibliographic_title":"Respiration; international review of thoracic diseases"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"BACKGROUND: Little is understood about the additive effects of leukotriene receptor antagonists (LTRA) on asthmatics currently medicated with inhaled corticosteroids (ICS) and long-acting beta(2)-agonists (LABA). OBJECTIVES: The present study examines the anti-inflammatory effects of the LTRA pranlukast in addition to ICS and LABA, among asthmatic patients with normal pulmonary function and unremarkable clinical symptoms. METHODS: Fifteen adult asthmatics participated in a 2-month, open-label, uncontrolled, prospective, multicenter, observational trial. Patients stabilized (predicted forced expiratory volume in 1 s >80%) by medication with ICS and LABA were also given pranlukast (450 mg daily). Asthma-related symptoms, pulmonary function, blood eosinophil counts and several inflammatory markers in sputum were monitored at week 0, as well as at 4 and 8 weeks after starting therapy with pranlukast. RESULTS: Adding pranlukast did not further improve blood eosinophil counts, pulmonary function and symptoms, but significantly attenuated sputum cysteinyl leukotrienes, tumor necrosis factor-alpha and interleukin-5 concentrations. CONCLUSIONS: Although the clinical relevance remains obscure, adding an LTRA attenuates allergic airway inflammation in some asthmatics undergoing treatment with ICS and LABA.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Respiration, 76(4), pp.398-402; 2008","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Karger AG"}]},"item_2_relation_11":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"18689991","subitem_relation_type_select":"PMID"}}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1159/000151289","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright c 2008 S. Karger AG, Basel"}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00816840","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00257931","subitem_source_identifier_type":"ISSN"}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"1423-0356","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Tomari, Shinya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsuse, Hiroto"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hirose, Hiroko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tsuchida, Tomoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fukahori, Susumu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fukushima, Chizu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kawano, Tetsuya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsuo, Nobuko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kohno, Shigeru"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-23"}],"displaytype":"detail","filename":"Respiration76_398.pdf","filesize":[{"value":"97.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Respiration76_398.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/16615/files/Respiration76_398.pdf"},"version_id":"1af00cfa-d36d-4c94-bc63-5731fc3b9c73"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Additive therapy","subitem_subject_scheme":"Other"},{"subitem_subject":"Airway inflammation","subitem_subject_scheme":"Other"},{"subitem_subject":"Asthma","subitem_subject_scheme":"Other"},{"subitem_subject":"Inhaled corticosteroid","subitem_subject_scheme":"Other"},{"subitem_subject":"Leukotriene receptor antagonist","subitem_subject_scheme":"Other"},{"subitem_subject":"Long-acting β2- agonist","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Observational study of the additive effects of pranlukast on inflammatory markers of clinically stable asthma with inhaled corticosteroids and long-acting beta 2 agonists.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Observational study of the additive effects of pranlukast on inflammatory markers of clinically stable asthma with inhaled corticosteroids and long-acting beta 2 agonists."}]},"item_type_id":"2","owner":"2","path":["30"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-11-24"},"publish_date":"2009-11-24","publish_status":"0","recid":"16615","relation_version_is_last":true,"title":["Observational study of the additive effects of pranlukast on inflammatory markers of clinically stable asthma with inhaled corticosteroids and long-acting beta 2 agonists."],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-17T20:40:34.855371+00:00"}