{"created":"2023-05-15T16:41:50.496761+00:00","id":16617,"links":{},"metadata":{"_buckets":{"deposit":"d9b79f78-f6bb-472d-9b5f-6442c0f9b599"},"_deposit":{"created_by":2,"id":"16617","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"16617"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00016617","sets":["8:9"]},"author_link":["63703","63702","63708","63706","63705","63707","63709","63704","63710","63711","63712"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"189","bibliographicPageStart":"180","bibliographicVolumeNumber":"29","bibliographic_titles":[{"bibliographic_title":"Journal of clinical immunology"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"INTRODUCTION: The high mobility group box 1 protein (HMGB-1)/advanced glycation end products (RAGE) system is recently shown to play an important part in immune/inflammatory disorders. However, the association of this system in systemic sclerosis (SSc) remains unknown. MATERIALS AND METHODS: To determine clinical association of serum levels of HMGB-1 and soluble RAGE (sRAGE) in patients with SSc, sera from 70 patients with SSc and 25 healthy controls were examined by enzyme-linked immunosorbent assay. Sera from tight-skin mice and bleomycin-induced scleroderma mice, animal models for SSc, were also examined. Skin HMGB-1 and RAGE expression was assessed by immunohistochemistry. RESULTS AND DISCUSSION: Serum HMGB-1 and sRAGE levels in SSc were higher than those in controls. Similarly, HMGB-1 and sRAGE levels in animal SSc models were higher than those in control mice. SSc patients with elevated HMGB-1 and sRAGE levels had more frequent involvement of several organs and immunological abnormalities compared to those with normal levels. Furthermore, HMGB-1 and sRAGE levels correlated positively with modified Rodnan total skin thickness score and negatively with pulmonary function test. CONCLUSIONS: HMGB-1 and sRAGE expression in the sclerotic skin was more intense than normal skin. These results suggest that elevated serum HMGB-1 and sRAGE levels are associated with the disease severity and immunological abnormalities in SSc.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Journal of clinical immunology, 29(2), pp.180-189; 2009","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Netherlands"}]},"item_2_relation_11":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"18825489","subitem_relation_type_select":"PMID"}}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1007/s10875-008-9252-x","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c Springer Science+Business Media, LLC 2008"},{"subitem_rights":"The original publication is available at www.springerlink.com"}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA10620335","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"02719142","subitem_source_identifier_type":"ISSN"}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"1573-2592","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yoshizaki, Ayumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Komura, Kazuhiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Iwata, Yohei"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ogawa, Fumihide"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hara, Toshihide"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Muroi, Eiji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takenaka, Motoi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shimizu, Kazuhiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hasegawa, Minoru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fujimoto, Manabu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sato, Shinichi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-23"}],"displaytype":"detail","filename":"JCI29_180.pdf","filesize":[{"value":"3.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"JCI29_180.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/16617/files/JCI29_180.pdf"},"version_id":"38ed4f9b-d3b8-44ef-b843-d55001afdc0c"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Autoimmune disease","subitem_subject_scheme":"Other"},{"subitem_subject":"HMGB-1","subitem_subject_scheme":"Other"},{"subitem_subject":"RAGE","subitem_subject_scheme":"Other"},{"subitem_subject":"Systemic sclerosis","subitem_subject_scheme":"Other"},{"subitem_subject":"Toll-like receptor","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Clinical significance of serum HMGB-1 and sRAGE levels in systemic sclerosis: association with disease severity.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Clinical significance of serum HMGB-1 and sRAGE levels in systemic sclerosis: association with disease severity."}]},"item_type_id":"2","owner":"2","path":["9"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-11-24"},"publish_date":"2009-11-24","publish_status":"0","recid":"16617","relation_version_is_last":true,"title":["Clinical significance of serum HMGB-1 and sRAGE levels in systemic sclerosis: association with disease severity."],"weko_creator_id":"2","weko_shared_id":2},"updated":"2023-05-15T18:57:49.743793+00:00"}