@article{oai:nagasaki-u.repo.nii.ac.jp:00016641,
 author = {Kosai, Kosuke and Seki, Masafumi and Yanagihara, Katsunori and Nakamura, Shigeki and Kurihara, Shintaro and Izumikawa, Koichi and Kakeya, Hiroshi and Yamamoto, Yoshihiro and Tashiro, Takayoshi and Kohno, Shigeru},
 issue = {4},
 journal = {Scandinavian journal of infectious diseases},
 month = {},
 note = {Plasma levels of high mobility group box chromosomal protein-1 (HMGB-1), as well as of other inflammatory molecules such as interleukin-6 (IL-6), regulated on activation normal T-cell expressed and secreted (RANTES), and soluble intercellular adhesion molecule-1 (sICAM-1), were determined in patients with bacterial pneumonia coinfected with influenza virus. HMGB-1 levels were significantly elevated in these patients compared to patients undergoing mild bacterial pneumonia alone (p < 0.01). Among cases of coinfection, we found a significant correlation between the concentration of HMGB-1 and white blood cell counts (p < 0.05, r = 0.612). Levels of IL-6 were also higher in these patients than in patients with bacterial pneumonia alone (p < 0.05), despite similar levels of RANTES and sICAM-1 in the 2 groups. These data suggest that HMGB-1 is involved in the pathogenesis of severe bacterial pneumonia coinfected with influenza virus., Scandinavian journal of infectious diseases, 40(4), pp.338-342; 2008},
 pages = {338--342},
 title = {Elevated levels of high mobility group box chromosomal protein-1 (HMGB-1) in sera from patients with severe bacterial pneumonia coinfected with influenza virus.},
 volume = {40},
 year = {2008}
}