@article{oai:nagasaki-u.repo.nii.ac.jp:00016654,
 author = {Yamada, Shin-ichi and Yanamoto, Souichi and Yoshida, Hajime and Yoshitomi, Izumi and Kawasaki, Goro and Mizuno, Akio and Nemoto, Takayuki K.},
 issue = {1},
 journal = {International journal of oral and maxillofacial surgery},
 month = {Jan},
 note = {alpha-actinin-4, originally identified as an actin-binding protein associated with cell motility, invasion, and metastasis of cancer cells, appears to be overexpressed in various human epithelial carcinomas, including colorectal, breast, esophageal, ovarian, and non-small cell lung carcinomas. The authors evaluated whether alpha-actinin-4 might be appropriate as a molecular target for cancer gene therapy. In 64 primary oral squamous cell carcinomas (OSCCs) and 10 normal oral mucosal specimens, and in seven human OSCC cell lines, alpha-actinin-4 expression was evaluated immunologically and correlations with clinicopathologic factors were examined. Overexpression of alpha-actinin-4 was detected in 38 of 64 oral squamous cell carcinomas (70%); significantly more frequently than in normal oral mucosa. The expression of alpha-actinin-4 was significantly associated with invasion potential defined by the Matrigel invasion assay. Cancer cell lines with higher alpha-actinin-4 expression had greater invasive potential. An RNAi-mediated decrease in alpha-actinin-4 expression reduced the invasion potential. These results indicated that the overexpression of alpha-actinin-4 was associated with an aggressive phenotype of OSCC. The study indicated that alpha-actinin-4 could be a potential molecular target for gene therapy by RNAi targeting for OSCC., International journal of oral and maxillofacial surgery, 39(1), pp.61-67; 2010},
 pages = {61--67},
 title = {RNAi-mediated down-regulation of alpha-actinin-4 decreases invasion potential in oral squamous cell carcinoma.},
 volume = {39},
 year = {2010}
}