@article{oai:nagasaki-u.repo.nii.ac.jp:00016688,
 author = {Kawano, Hiroaki and Sengyoku, Hideyori and Satoh, Osami and Urabe, Shigetoshi and Koide, Yuji and Yano, Katsusuke},
 issue = {12},
 journal = {Internal Medicine},
 month = {Jun},
 note = {We report a 16-year-old man with severe heart failure due to idiopathic pulmonary arterial hypertension (IPAH). The patient was initially treated with a combination of beraprost, a prostacyclin analog, and sarpogrelate, a serotonin receptor inhibitor. However, he was unresponsive to the treatment. We then changed the treatment to sildenafil, and his condition dramatically improved. Sildenafil has an immediate pulmonary vasodilator effect in patients already receiving vasodilators for IPAH., Internal Medicine, vol.46(12), pp.893-898; 2007},
 pages = {893--898},
 title = {Marked Improvement with Sildenafil in a Patient with Idiopathic Pulmonary Arterial Hypertension Unresponsive to Beraprost and Sarpogrelate},
 volume = {46},
 year = {2007}
}