{"created":"2023-05-15T16:41:54.531541+00:00","id":16708,"links":{},"metadata":{"_buckets":{"deposit":"ad924794-83d9-4094-bb3f-04f067fb3183"},"_deposit":{"created_by":2,"id":"16708","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"16708"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00016708","sets":["10:11"]},"author_link":["64358","64357","64356"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-01-05","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1-2","bibliographicPageEnd":"34","bibliographicPageStart":"29","bibliographicVolumeNumber":"683","bibliographic_titles":[{"bibliographic_title":"Mutation research"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Ionizing radiation induces delayed destabilization of the genome in the progenies of surviving cells. This phenomenon, which is called radiation-induced genomic instability, is manifested by delayed induction of radiation effects, such as cell death, chromosome aberration, and mutation in the progeny of cells surviving radiation exposure. Previously, there was a report showing that delayed cell death was absent in Ku80-deficient Chinese hamster ovary (CHO) cells, however, the mechanism of their defect has not been determined. We found that delayed induction of DNA double strand breaks and chromosomal breaks were intact in Ku80-deficient cells surviving X-irradiation, whereas there was no sign for the production of chromosome bridges between divided daughter cells. Moreover, delayed induction of dicentric chromosomes was significantly compromised in those cells compared to the wild-type CHO cells. Reintroduction of the human Ku86 gene complimented the defective DNA repair and recovered delayed induction of dicentric chromosomes and delayed cell death, indicating that defective Ku80-dependent dicentric induction was the cause of the absence of delayed cell death. Since DNA-PKcs-defective cells showed delayed phenotypes, Ku80-dependent illegitimate rejoining is involved in delayed impairment of the integrity of the genome in radiation-survived cells.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Mutation research, 683(1-2), pp.29-34; 2010","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier B.V."}]},"item_2_relation_11":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"19822159","subitem_relation_type_select":"PMID"}}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.mrfmmm.2009.10.003","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright c 2009 Elsevier B.V. All rights reserved."}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA10747915","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"13861964","subitem_source_identifier_type":"ISSN"}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"0027-5107","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Suzuki, Keiji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kodama, Seiji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Watanabe, Masami"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-23"}],"displaytype":"detail","filename":"MutRes_Suzuki.pdf","filesize":[{"value":"225.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"MutRes_Suzuki.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/16708/files/MutRes_Suzuki.pdf"},"version_id":"07fd2909-a3ce-4a67-a68b-94b1d249980c"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"CHO","subitem_subject_scheme":"Other"},{"subitem_subject":"Chromosome aberration","subitem_subject_scheme":"Other"},{"subitem_subject":"DNA repair","subitem_subject_scheme":"Other"},{"subitem_subject":"Genomic instability","subitem_subject_scheme":"Other"},{"subitem_subject":"Ionizing radiation","subitem_subject_scheme":"Other"},{"subitem_subject":"Non-homologous end-joining","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Role of Ku80-dependent end-joining in delayed genomic instability in mammalian cells surviving ionizing radiation.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Role of Ku80-dependent end-joining in delayed genomic instability in mammalian cells surviving ionizing radiation."}]},"item_type_id":"2","owner":"2","path":["11"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-12-04"},"publish_date":"2009-12-04","publish_status":"0","recid":"16708","relation_version_is_last":true,"title":["Role of Ku80-dependent end-joining in delayed genomic instability in mammalian cells surviving ionizing radiation."],"weko_creator_id":"2","weko_shared_id":2},"updated":"2023-05-15T18:55:26.888901+00:00"}