@article{oai:nagasaki-u.repo.nii.ac.jp:00016709,
 author = {Shibata, Itsuko and Yoshitomi, Osamu and Use, Tadasuke and Ureshino, Hiroyuki and Cho, Sungsam and Maekawa, Takuji and Hara, Tetsuya and Sumikawa, Koji},
 issue = {4},
 journal = {Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy},
 month = {Aug},
 note = {OBJECTIVES: We assessed the effect of administration time for fasudil treatment of the stunned myocardium in 40 anesthetized open chest swine. MATERIALS AND METHODS: All swine were subjected to 12 min ischemia followed by reperfusion to generate stunned myocardium. Group A (n = 11) received saline in place of fasudil both before ischemia and after reperfusion. Group B (n = 10) received 30 min intravenous fasudil at a rate of 13 mug/kg/min starting 45 min before ischemia and received saline after reperfusion. Groups C (n = 10) and D (n = 9) received saline before ischemia, and received fasudil at a rate of 13 microg kg(-1) min(-1) starting just before reperfusion in group C and 30 min after reperfusion in group D. In both groups, treatment lasted 30 min. Myocardial contractility was assessed by percent segment shortening (%SS). RESULTS AND DISCUSSION: Three swine in group A, 2 swine in each of groups B and C, and one swine in group D had ventricular fibrillation or tachycardia after reperfusion and were excluded from further analysis. The changes of %SS from baseline at 90 min after reperfusion in groups B and C were 68 +/- 8% and 75 +/- 8%, respectively, which were significantly higher than in group A or D (47 +/- 10% or 43 +/- 8%). CONCLUSION: We conclude that fasudil administered before ischemia or just after reperfusion, but not 30 min after reperfusion, protects the stunned myocardium., Cardiovascular Drugs and Therapy, 22(4), pp.293-298; 2008},
 pages = {293--298},
 title = {Administration of the Rho-kinase inhibitor fasudil before ischemia or just after reperfusion, but not 30 min after reperfusion, protects the stunned myocardium in swine.},
 volume = {22},
 year = {2008}
}