{"created":"2023-05-15T16:41:54.575440+00:00","id":16709,"links":{},"metadata":{"_buckets":{"deposit":"c51fcd66-6d14-4577-acfc-03d634f0bbbe"},"_deposit":{"created_by":2,"id":"16709","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"16709"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00016709","sets":["8:9"]},"author_link":["64364","64366","64365","64359","64361","64363","64360","64362"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"298","bibliographicPageStart":"293","bibliographicVolumeNumber":"22","bibliographic_titles":[{"bibliographic_title":"Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"OBJECTIVES: We assessed the effect of administration time for fasudil treatment of the stunned myocardium in 40 anesthetized open chest swine. MATERIALS AND METHODS: All swine were subjected to 12 min ischemia followed by reperfusion to generate stunned myocardium. Group A (n = 11) received saline in place of fasudil both before ischemia and after reperfusion. Group B (n = 10) received 30 min intravenous fasudil at a rate of 13 mug/kg/min starting 45 min before ischemia and received saline after reperfusion. Groups C (n = 10) and D (n = 9) received saline before ischemia, and received fasudil at a rate of 13 microg kg(-1) min(-1) starting just before reperfusion in group C and 30 min after reperfusion in group D. In both groups, treatment lasted 30 min. Myocardial contractility was assessed by percent segment shortening (%SS). RESULTS AND DISCUSSION: Three swine in group A, 2 swine in each of groups B and C, and one swine in group D had ventricular fibrillation or tachycardia after reperfusion and were excluded from further analysis. The changes of %SS from baseline at 90 min after reperfusion in groups B and C were 68 +/- 8% and 75 +/- 8%, respectively, which were significantly higher than in group A or D (47 +/- 10% or 43 +/- 8%). CONCLUSION: We conclude that fasudil administered before ischemia or just after reperfusion, but not 30 min after reperfusion, protects the stunned myocardium.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Cardiovascular Drugs and Therapy, 22(4), pp.293-298; 2008","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Netherlands"}]},"item_2_relation_11":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"18470606","subitem_relation_type_select":"PMID"}}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1007/s10557-008-6106-y","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c Springer Science+Business Media, LLC 2008"},{"subitem_rights":"The original publication is available at www.springerlink.com"}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA10691796","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"09203206","subitem_source_identifier_type":"ISSN"}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"1573-7241","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Shibata, Itsuko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yoshitomi, Osamu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Use, Tadasuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ureshino, Hiroyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Cho, Sungsam"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Maekawa, Takuji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hara, Tetsuya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sumikawa, Koji"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-23"}],"displaytype":"detail","filename":"CDT22_293.pdf","filesize":[{"value":"441.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"CDT22_293.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/16709/files/CDT22_293.pdf"},"version_id":"c4d1fe4f-0c69-4e49-8ee4-446d6990cc75"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Fasudil","subitem_subject_scheme":"Other"},{"subitem_subject":"Ischemia","subitem_subject_scheme":"Other"},{"subitem_subject":"Reperfusion","subitem_subject_scheme":"Other"},{"subitem_subject":"Rho-kinase","subitem_subject_scheme":"Other"},{"subitem_subject":"Stunned myocardium","subitem_subject_scheme":"Other"},{"subitem_subject":"Swine","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Administration of the Rho-kinase inhibitor fasudil before ischemia or just after reperfusion, but not 30 min after reperfusion, protects the stunned myocardium in swine.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Administration of the Rho-kinase inhibitor fasudil before ischemia or just after reperfusion, but not 30 min after reperfusion, protects the stunned myocardium in swine."}]},"item_type_id":"2","owner":"2","path":["9"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-12-07"},"publish_date":"2009-12-07","publish_status":"0","recid":"16709","relation_version_is_last":true,"title":["Administration of the Rho-kinase inhibitor fasudil before ischemia or just after reperfusion, but not 30 min after reperfusion, protects the stunned myocardium in swine."],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-17T20:39:37.925284+00:00"}