{"created":"2023-05-15T16:41:54.878854+00:00","id":16716,"links":{},"metadata":{"_buckets":{"deposit":"d6948552-efe7-448c-8323-1c7c5bd91f8d"},"_deposit":{"created_by":2,"id":"16716","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"16716"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00016716","sets":["8:9"]},"author_link":["64431","64446","64430","64426","64422","64437","64439","64440","64447","64433","64428","64444","64423","64429","64441","64442","64443","64427","64424","64436","64445","64438","64435","64432","64434","64425"],"item_2_alternative_title_19":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Clinical Evaluation of New Radioimmunoassay for ICA 512/IA-2 Autoantibodies - Comparative Analysis with Radioligand Binding Assay -"}]},"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2000-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"12","bibliographicPageEnd":"1056","bibliographicPageStart":"1051","bibliographicVolumeNumber":"43","bibliographic_titles":[{"bibliographic_title":"糖尿病"},{"bibliographic_title":"Journal of the Japan Diabetes Society","bibliographic_titleLang":"en"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"1型糖尿病における新しい膵島自己抗体として発見されたICA512/lA-2抗体の一般臨床での測定を目的としたキット(RIA法)が開発された.今回われわれは,キットの判定の正確さを明らかにするために,1型糖尿病患者72例.2型糖尿病患者127例および健常人71例の血清を用いて,従来使用されている高感度のradioligand binding assay法(RBA法)と,その1型糖尿病における疾患感度および特異性を比較検討した.RIA法およびRBA法によるICA512/lA-2抗体の陽性率は,1型糖尿病で43.1%と48.6%,2型糖尿病で3.9%と2.4%であり,健常者においては検出されなかった(特異性100%).両測定法の抗体価は有意な相関(r=0.744,p<0.0001)を示したが,RBA法での抗体価が低くなるにしたがいRIA法で陰性となる血清が多く認められた.Standard deviation scoreを用いた検討では,RBA法で高抗体価であるにもかかわらずRIA法で低抗体価である血清がみられた.本ICA512/lA-2抗体測定キットは特異性には優れているが,疾患感度はRBA法にやや劣るため,RIA法で陰性の場合には高感度法での再検や,他の膵島自己抗体との組み合わせが必要と考えられた.","subitem_description_type":"Abstract"},{"subitem_description":"To determine the assay accuracy of a newly developed radioimmunoassay (RIA) kit for ICA 512/IA-2 autoantibodies, we analyzed kit disease sensitivity and specificity compared to highly sensitive radioligand binding assay (RBA) using sera from 72 patients with type 1 diabetes, 127 patients with type 2 diabetes, and 71 healthy subjects. The prevalence of ICA 512/IA-2 autoantibodies by RIA and RBA were 43.1% and 48.6% in type 1 diabetics, and 3.9% and 2.4% in type 2 diabetics. No healthy subjects were positive in either assay (specificity 100%). Although ICA 512/IA-2 autoantibody levels correlated significantly between RIA and REA, some sera showed negative results in RIA but positive in RBA in a low titer range. With analysis using the standard deviation score (SDS) in each serum from patients with type 1 diabetes, we observed some sera with high SDS by RBA but low SDS by RIA even though all were positive. The newly developed RIA has high specificity but lower disease sensitivity than RBA. Re-evaluation of the sera using the assay with higher sensitivity or combined analysis with other islet-autoantibodies required in type 1 diabetic patients negative for ICA 512/IA-2 autoantibodies measured by this RIA.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"糖尿病, 43(12), pp. 1051-1056; 2001","subitem_description_type":"Other"}]},"item_2_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"64435","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Kawasaki, Eiji"}]},{"nameIdentifiers":[{"nameIdentifier":"64436","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Sera, Yasunori"}]},{"nameIdentifiers":[{"nameIdentifier":"64437","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Fujita, Naruhiro"}]},{"nameIdentifiers":[{"nameIdentifier":"64438","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Abe, Takahiro"}]},{"nameIdentifiers":[{"nameIdentifier":"64439","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Yamauchi, Mikako"}]},{"nameIdentifiers":[{"nameIdentifier":"64440","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Ozaki, Masako"}]},{"nameIdentifiers":[{"nameIdentifier":"64441","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Miyazoe, Haruko"}]},{"nameIdentifiers":[{"nameIdentifier":"64442","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Yamakawa, Kenichi"}]},{"nameIdentifiers":[{"nameIdentifier":"64443","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Uotani, Shigeo"}]},{"nameIdentifiers":[{"nameIdentifier":"64444","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Takino, Hirofumi"}]},{"nameIdentifiers":[{"nameIdentifier":"64445","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Yamasaki, Hironori"}]},{"nameIdentifiers":[{"nameIdentifier":"64446","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Yamaguchi, Yoshihiko"}]},{"nameIdentifiers":[{"nameIdentifier":"64447","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Eguchi, Katsumi"}]}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本糖尿病学会"}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright (c) 日本糖尿病学会"}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00166576","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0021437X","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"川崎, 英二"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"世羅, 康徳"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"藤田, 成裕"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"安部, 幸弘"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"山内, 三爵子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"尾崎, 方子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"宮副, 治子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"山川, 賢一"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"魚谷, 茂雄"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"瀧野, 博文"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"山崎, 浩則"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"山口, 義彦"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"江口, 勝美"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-23"}],"displaytype":"detail","filename":"tonyobyo43_1051.pdf","filesize":[{"value":"362.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"tonyobyo43_1051.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/16716/files/tonyobyo43_1051.pdf"},"version_id":"d14f7f0c-e998-4ee6-972b-1fb25cc65126"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ICA 512抗体","subitem_subject_scheme":"Other"},{"subitem_subject":"IA-2抗体","subitem_subject_scheme":"Other"},{"subitem_subject":"1型糖尿病","subitem_subject_scheme":"Other"},{"subitem_subject":"膵島自己抗体","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ICA512/IA-2抗体新規RIA報の臨床的評価 - Radioligand binding assay法との比較検討 -","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ICA512/IA-2抗体新規RIA報の臨床的評価 - Radioligand binding assay法との比較検討 -"}]},"item_type_id":"2","owner":"2","path":["9"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-12-07"},"publish_date":"2009-12-07","publish_status":"0","recid":"16716","relation_version_is_last":true,"title":["ICA512/IA-2抗体新規RIA報の臨床的評価 - Radioligand binding assay法との比較検討 -"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-17T20:39:29.498419+00:00"}