{"created":"2023-05-15T16:41:56.170853+00:00","id":16746,"links":{},"metadata":{"_buckets":{"deposit":"10659982-f61e-424c-a2f3-d39f1c5f9b09"},"_deposit":{"created_by":2,"id":"16746","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"16746"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00016746","sets":["35:36"]},"author_link":["64641","64642","64643","64644","64638","64640","64639","64645"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2005-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"271","bibliographicPageStart":"268","bibliographicVolumeNumber":"58","bibliographic_titles":[{"bibliographic_title":"Japanese Journal of Infectious Diseases"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Cerebral malaria (CM) is a serious complication of Plasmodium falciparum malaria, and its pathogenesis leading to coma remains unknown. Heme oxygenase-1 (HO-1) catalyzes heme breakdown, eventually generating bilirubin, iron and carbon monoxide. The HO-1 gene promoter contains a polymorphic (GT)n repeat which may influence the expression level of HO-1. To explore the correlation between this (GT)n polymorphism and susceptibility to CM, we analyzed the frequencies of the (GT)n alleles in 120 Myanmarese patients with uncomplicated malaria (UM) and 30 patients with CM. The frequency of homozygotes for the short (GT)n alleles (<28 repeats) in CM patients was significantly higher than those in UM patinets (P < 0.008, OR = 3.14). Thus, short (GT)n alleles represent a genetic risk factor for CM.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Japanese Journal of Infectious Diseases, 58(5), pp. 268-271; 2005","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"National Institute of Infectious Diseases"}]},"item_2_relation_11":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"16249618","subitem_relation_type_select":"PMID"}}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA1132885X","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"13446304","subitem_source_identifier_type":"ISSN"}]},"item_2_text_62":{"attribute_name":"出版者別言語","attribute_value_mlt":[{"subitem_text_value":"国立感染症研究所"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Takeda, Masato"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kikuchi, Mihoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ubalee, Ratawan"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Na-Bangchang, Kesara"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ruangweerayut, Ronnatrai"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shibahara, Shigeki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Imaiand, So-ichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hirayama, Kenji"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-23"}],"displaytype":"detail","filename":"JJID58_268.pdf","filesize":[{"value":"72.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"JJID58_268.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/16746/files/JJID58_268.pdf"},"version_id":"37bd3978-a8e3-4329-a589-b90ed67bd66c"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Microsatellite Polymorphism in the Heme Oxygenase-1 Gene Promoter Is Associated with Susceptibility to Cerebral Malaria in Myanmar","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Microsatellite Polymorphism in the Heme Oxygenase-1 Gene Promoter Is Associated with Susceptibility to Cerebral Malaria in Myanmar"}]},"item_type_id":"2","owner":"2","path":["36"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-12-14"},"publish_date":"2009-12-14","publish_status":"0","recid":"16746","relation_version_is_last":true,"title":["Microsatellite Polymorphism in the Heme Oxygenase-1 Gene Promoter Is Associated with Susceptibility to Cerebral Malaria in Myanmar"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-17T20:38:11.863946+00:00"}