{"created":"2023-05-15T16:41:57.402111+00:00","id":16775,"links":{},"metadata":{"_buckets":{"deposit":"f784f89c-8907-4b26-8182-0769e69d2c79"},"_deposit":{"created_by":2,"id":"16775","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"16775"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00016775","sets":["8:9"]},"author_link":["64825","64822","64818","64817","64823","64819","64826","64816","64820","64824","64821"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-05","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"7","bibliographicPageEnd":"878","bibliographicPageStart":"871","bibliographicVolumeNumber":"30","bibliographic_titles":[{"bibliographic_title":"Rheumatology international"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The objective of the study was to determine the presence or levels of antibodies (Abs) against caspase-3 and their clinical relevance in systemic sclerosis (SSc). Anti-caspase-3 Ab was examined by enzyme-linked immunosorbent assay and immunoblotting. IgG anti-caspase-3 Ab levels in SSc patients were higher than in normal controls. SSc patients positive for IgG anti-caspase-3 Ab had significantly longer disease duration, more frequent presence of decreased %VC and %DLco, and elevated levels of serum immunoglobulin and erythrocyte sedimentation rates. IgG anti-caspase-3 Ab levels correlated positively with serum IgG levels, renal vascular resistance, and serum levels of 8-isoprostane. Immunoblotting analysis confirmed the presence of anti-caspase-3 Ab in sera from SSc patients. Caspase-3 enzymatic activity was inhibited by IgG isolated from SSc sera containing IgG anti-caspase-3 Ab. These results suggest that autoantibody against caspase-3 is generated in SSc and that this Ab is related to the severity of pulmonary fibrosis, vascular damage, and inflammation.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Rheumatology international, 30(7), pp.871-878; 2010","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Berlin"}]},"item_2_relation_11":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"19639321","subitem_relation_type_select":"PMID"}}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1007/s00296-009-1068-3","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c Springer-Verlag 2009"},{"subitem_rights":"The original publication is available at www.springerlink.com"}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA0040456X","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"01728172","subitem_source_identifier_type":"ISSN"}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"1437-160X","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Okazaki, Shihoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ogawa, Fumihide"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Iwata, Yohei"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hara, Toshihide"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Muroi, Eiji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Komura, Kazuhiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takenaka, Motoi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shimizu, Kazuhiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hasegawa, Minoru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fujimoto, Manabu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sato, Shinichi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-23"}],"displaytype":"detail","filename":"RheInt_Okazaki.pdf","filesize":[{"value":"1.8 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"RheInt_Okazaki.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/16775/files/RheInt_Okazaki.pdf"},"version_id":"d55211cb-7fb8-483d-a60f-cacd8997cdbe"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Autoantibody","subitem_subject_scheme":"Other"},{"subitem_subject":"Caspase-3","subitem_subject_scheme":"Other"},{"subitem_subject":"Pulmonary fibrosis","subitem_subject_scheme":"Other"},{"subitem_subject":"Renal vascular damage","subitem_subject_scheme":"Other"},{"subitem_subject":"Systemic sclerosis","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Autoantibody against caspase-3, an executioner of apoptosis, in patients with systemic sclerosis.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Autoantibody against caspase-3, an executioner of apoptosis, in patients with systemic sclerosis."}]},"item_type_id":"2","owner":"2","path":["9"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-12-25"},"publish_date":"2009-12-25","publish_status":"0","recid":"16775","relation_version_is_last":true,"title":["Autoantibody against caspase-3, an executioner of apoptosis, in patients with systemic sclerosis."],"weko_creator_id":"2","weko_shared_id":2},"updated":"2023-05-15T18:44:06.434574+00:00"}