@article{oai:nagasaki-u.repo.nii.ac.jp:00016779, author = {Yamada, Yasuaki and Okada, Masahiko and Kamitamari, Akira and Moriuchi, Hiroyuki and Yanai, Masanori and Hano, Osamu and Tsukasaki, Kunihiro and Tsuruda, Kazuto and Hasegawa, Hiroo and Yanagihara, Katsunori and Kamihira, Shimeru}, issue = {22}, journal = {Internal Medicine}, month = {}, note = {Idiopathic CD4+ T-lymphocytopenia (ICL) is a new disease entity characterized by CD4+ T-lymphocyte depletion without evidence of HIV infection. We report a 27-year-old ICL patient with a long history of multiple immune abnormalities. His CD4+ T-lymphocyte count started to decrease after generalized lymphadenopathy of an unknown cause at age 3. He satisfied the criteria for ICL at age 9, and the decreased CD4+ Tlymphocyte count persisted for more than 18 years. This is probably the first childhood-onset ICL case in which the trigger event for the development was known together with the patient's autoimmune background., Internal Medicine, 48(22), pp.1967-1971; 2009}, pages = {1967--1971}, title = {Multiple Immune Abnormalities in a Patient with Idiopathic CD4+ T-Lymphocytopenia}, volume = {48}, year = {2009} }