{"created":"2023-05-15T16:30:31.238307+00:00","id":1680,"links":{},"metadata":{"_buckets":{"deposit":"174b2ee7-9916-4ed0-a78f-abe114740556"},"_deposit":{"created_by":2,"id":"1680","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"1680"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00001680","sets":["35:36"]},"author_link":["8145","8148","8150","8139","8149","8141","8138","8140","8137","8146","8143","8147","8142","8151","8144"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-03-13","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageStart":"10","bibliographicVolumeNumber":"18","bibliographic_titles":[{"bibliographic_title":"Annals of Clinical Microbiology and Antimicrobials"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: Considerable progress has been made in dengue management, however the lack of appropriate predictors of severity has led to huge number of unwanted admissions mostly decided on the grounds of warning signs. Apoptosis related mediators,among others, are known to correlate with severe dengue (SD) although no predictive validity is established. The objective of this study was to investigate the association of plasma cell-free DNA (cfDNA) with SD, and evaluate its prognostic value in SD prediction at acute phase. Methods: This was a hospital-based prospective cohort study conducted in Vietnam.All the recruited patients were required to be admitted to the hospital and were strictly monitored for various laboratory and clinical parameters(including progression to SD) until discharged. Plasma samples collected during acute phase (6-48 h before defervescence) were used to estimate the level of cfDNA. Results: Of the 61 dengue patients,SD patients (n = 8)developed shock syndrome in 4.8 days (95% CI 3.7-5.4) after the fever onset. Plasma cfDNA levels\n before the defervescence of SD patients were significantly higher than the non-SD group (p = 0.0493). From the receiver operating characteristic (ROC) curve analysis, a cut-off of > 36.9 ng/mL was able to predict SD with a good sensitivity (87.5%), specificity (54.7%), and area under the curve (AUC) (0.72, 95% CI 0.55-0.88; p = 0.0493).Conclusions: Taken together, these findings suggest that cfDNA could serve as a potential prognostic biomarker of SD. \nStudies with cfDNA kinetics and its combination with other biomarkers and clinical parameters would further improve \nthe diagnostic ability for SD.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Annals of Clinical Microbiology and Antimicrobials, 18(1), art.no.10; 2019","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"BioMed Central Ltd."}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1186/s12941-019-0309-x","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c The Author(s) 2019. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creat iveco mmons .org/licen ses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license,and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated."}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"14760711","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Phuong, Nguyen Thi Ngoc"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Manh, Dao Huy"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Dumre, Shyam Prakash"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mizukami, Shusaku"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Weiss, Lan Nguyen"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Van, Thuong  Nguyen"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ha, Tran Thi Ngoc"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Phuc, Le Hong"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Van, An  Tran"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tieu, Thuan Minh"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kamel, Mohamed Gomaa"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Morra, Mostafa Ebraheem"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Huong, Vu Thi Que"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Huy, Nguyen Tien"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hirayama, Kenji"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-18"}],"displaytype":"detail","filename":"ACMA18_10.pdf","filesize":[{"value":"826.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ACMA18_10.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/1680/files/ACMA18_10.pdf"},"version_id":"38ace0d4-a148-4630-8e95-6c0127950bee"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Cell-free DNA","subitem_subject_scheme":"Other"},{"subitem_subject":"Dengue severity predictor","subitem_subject_scheme":"Other"},{"subitem_subject":"Prognostic biomarker　","subitem_subject_scheme":"Other"},{"subitem_subject":"Severe dengue","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Plasma cell-free DNA: a potential biomarker for early prediction of severe dengue","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Plasma cell-free DNA: a potential biomarker for early prediction of severe dengue"}]},"item_type_id":"2","owner":"2","path":["36"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-04-10"},"publish_date":"2019-04-10","publish_status":"0","recid":"1680","relation_version_is_last":true,"title":["Plasma cell-free DNA: a potential biomarker for early prediction of severe dengue"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T03:58:11.184528+00:00"}