@article{oai:nagasaki-u.repo.nii.ac.jp:00016823,
 author = {Eguchi, Susumu and Matsumoto, Shigehiro and Hamasaki, Koji and Takatsuki, Mitsuhisa and Hidaka, Masaaki and Tajima, Yoshitsugu and Sakamoto, Ichiro and Kanematsu, Takashi},
 issue = {6},
 journal = {Journal of hepato-biliary-pancreatic surgery},
 month = {Nov},
 note = {BACKGROUND/PURPOSE: While lipiodolized transarterial chemoembolization (lip-TACE) is effective for treating unresectable hepatocellular carcinoma (HCC), its effect for treating recurrent HCC after curative liver resection needs to be clarified. METHODS: Of 163 patients who had undergone curative liver resection between 1992 and December 2003, 65 patients (39.8%) had recurrent HCC in the liver without extrahepatic recurrence and were indicated for lip-TACE. The overall survival rate after lip-TACE was calculated, and its correlation with factors such as the histology of the primary HCC and background noncancerous tissue were analyzed. RESULTS: The overall survival rates after lip-TACE after the detection of the first recurrent HCC were 82.6%, 44.5%, and 24.8% at 1, 3, and 5 years, respectively. The factors affecting patient survival after lip-TACE were microscopic portal venous involvement of HCC at liver resection, grade of inflammation in the noncancerous liver parenchyma, and recurrence within 1 year after the initial liver resection. Multivariate analysis showed that the period between the resection and first recurrence had the highest hazard ratio. CONCLUSIONS: Lip-TACE is a reasonable procedure for treating recurrent HCC in selected patients who are not eligible for hepatic re-resection. When HCC recurred within 1 year from the primary liver resection, the effect of lip-TACE on patient survival was limited., Journal of hepato-biliary-pancreatic surgery, 15(6), pp.627-633; 2008},
 pages = {627--633},
 title = {Re-evaluation of lipiodolized transarterial chemoembolization therapy for intrahepatic recurrence of hepatocellular carcinoma after curative liver resection.},
 volume = {15},
 year = {2008}
}