@article{oai:nagasaki-u.repo.nii.ac.jp:00016875,
 author = {Moriuchi, Hiroki and Kamohara, Yukio and Eguchi, Susumu and Gu, Weili and Fujioka, Hikaru and Yamamoto, Takao and Tajima, Yoshitsugu and Kanematsu, Takashi and Koji, Takehiko},
 issue = {1},
 journal = {The Journal of surgical research},
 month = {May},
 note = {BACKGROUND: The current study investigated whether FK506 (FK) regulates the apoptotic systems in allografted rat liver and the contribution of Fas/Fas-ligand system and Bcl-2 family during acute rejection. MATERIALS AND METHODS: The recipients were divided into three groups, the allo, the allo-FK, and the syn group. Rats were euthanized 1, 3, 5, and 7 d after OLT. Apoptotic activity was explored using terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL) assay. The expression of Fas/Fas-ligand and Bcl-2/Bax in the grafted livers was investigated by Western blotting and immunohistochemistry. RESULTS: The apoptotic index (AI) of hepatocytes in the allo-FK group was less than that in the allo group. Fas in the allo group was more intense than that in the allo-FK group in the periportal areas on day 1 and 3, while Bcl-2 in the allo group was less intense than that in the allo-FK group in the pericaval areas at all time-points after OLT. CONCLUSION: FK provides beneficial antiapoptotic effects on hepatocytes in the grafted rat livers through both the down-regulation of Fas expression in the periportal areas and the up-regulation of Bcl-2 expression in the pericaval areas., The Journal of surgical research, 167(1), pp.131-139; 2011},
 pages = {131--139},
 title = {Diverse Effects of FK506 on the Apoptosis of Hepatocytes and Infiltrating Lymphocytes in an Allografted Rat Liver.},
 volume = {167},
 year = {2011}
}