@article{oai:nagasaki-u.repo.nii.ac.jp:00001688, author = {Sakamoto, Noriho and Ishimoto, Hiroshi and Nakashima, Shota and Yura, Hirokazu and Miyamura, Takuto and Okuno, Daisuke and Hara, Atsuko and Kitazaki, Takeshi and Kakugawa, Tomoyuki and Ishimatsu, Yuji and Satoh, Minoru and Mukae, Hiroshi}, issue = {6}, journal = {Internal Medicine}, month = {Mar}, note = {Anti-melanoma differentiation-associated gene 5 (anti-MDA5) antibody is associated with rapidly progressive interstitial lung disease (RP-ILD) in patients with clinically amyopathic dermatomyositis (CADM) or dermatomyositis (DM). We herein report three Japanese cases of anti-MDA5 antibody-positive RP-ILD without signs of CADM or DM. High-resolution computed tomography revealed patchy or subpleural distribution of consolidations and/or ground-glass opacities accompanied by traction bronchiectasis. All patients succumbed to respiratory failure within two months. Anti-MDA5 antibody-positive RP-ILD without signs of CADM or DM should be included in the differential diagnosis of acute/subacute ILD. Measurement of anti-MDA5 antibody and an intensive immunosuppressive regimen might rescue these patients from RP-ILD., Internal medicine, 58(6), pp.837-841; 2019}, pages = {837--841}, title = {Clinical Features of Anti-MDA5 Antibody-positive Rapidly Progressive Interstitial Lung Disease without Signs of Dermatomyositis}, volume = {58}, year = {2019} }