{"created":"2023-05-15T16:42:02.227465+00:00","id":16888,"links":{},"metadata":{"_buckets":{"deposit":"fdb87618-df07-4913-bf34-aac75848694d"},"_deposit":{"created_by":2,"id":"16888","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"16888"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00016888","sets":["10:11"]},"author_link":["65595","65596","65594","65598","65604","65600","65601","65602","65599","65605","65597","65603"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-03-21","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"724","bibliographicPageStart":"719","bibliographicVolumeNumber":"367","bibliographic_titles":[{"bibliographic_title":"Biochemical and biophysical research communications"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Insulin peptide B:9-23 is a major autoantigen in type 1 diabetes. Combined treatment with B:9-23 peptide and polyinosinic-polycytidylic acid (poly I:C), but neither alone, induce insulitis in normal BALB/c mice. In contrast, the combined treatment accelerated insulitis, but prevented diabetes in NOD mice. Our immunofluorescence study with anti-CD4/anti-Foxp3 revealed that the proportion of Foxp3 positive CD4(+)CD25(+) regulatory T cells (Tregs) was elevated in the islets of NOD mice treated with B:9-23 peptide and poly I:C, as compared to non-treated mice. Depletion of Tregs by anti-CD25 antibody hastened spontaneous development of diabetes in non-treated NOD mice, and abolished the protective effect of the combined treatment and conversely accelerated the onset of diabetes in the treated mice. These results indicate that poly I:C combined with B:9-23 peptide promotes infiltration of both pathogenic T cells and predominantly Tregs into the islets, thereby inhibiting progression from insulitis to overt diabetes in NOD mice.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Biochemical and biophysical research communications, 367(4), pp.719-724; 2008","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier Inc."}]},"item_2_relation_11":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"18194666","subitem_relation_type_select":"PMID"}}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.bbrc.2007.12.191","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright c 2008 Elsevier Inc. All rights reserved."}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00564395","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0006291X","subitem_source_identifier_type":"ISSN"}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"1090-2104","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Fukushima, Keiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Abiru, Norio"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nagayama, Yuji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kobayashi, Masakazu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Satoh, Tsuyoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakahara, Mami"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kawasaki, Eiji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamasaki, Hironori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ueha, Satoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsushima, Koji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Liu, Edwin"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Eguchi, Katsumi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-23"}],"displaytype":"detail","filename":"BBRC367_719.pdf","filesize":[{"value":"537.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"BBRC367_719.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/16888/files/BBRC367_719.pdf"},"version_id":"edf1072b-5eae-4f93-9036-eb16aac36f9b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"CD4+ T cell","subitem_subject_scheme":"Other"},{"subitem_subject":"Insulin","subitem_subject_scheme":"Other"},{"subitem_subject":"Insulitis","subitem_subject_scheme":"Other"},{"subitem_subject":"Non-obese diabetic mouse","subitem_subject_scheme":"Other"},{"subitem_subject":"Peptide","subitem_subject_scheme":"Other"},{"subitem_subject":"Polyinosinic-polycytidylic acid","subitem_subject_scheme":"Other"},{"subitem_subject":"Regulatory T cell","subitem_subject_scheme":"Other"},{"subitem_subject":"Type 1 diabetes","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Combined insulin B:9-23 self-peptide and polyinosinic-polycytidylic acid accelerate insulitis but inhibit development of diabetes by increasing the proportion of CD4+Foxp3+ regulatory T cells in the islets in non-obese diabetic mice.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Combined insulin B:9-23 self-peptide and polyinosinic-polycytidylic acid accelerate insulitis but inhibit development of diabetes by increasing the proportion of CD4+Foxp3+ regulatory T cells in the islets in non-obese diabetic mice."}]},"item_type_id":"2","owner":"2","path":["11"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-01-28"},"publish_date":"2010-01-28","publish_status":"0","recid":"16888","relation_version_is_last":true,"title":["Combined insulin B:9-23 self-peptide and polyinosinic-polycytidylic acid accelerate insulitis but inhibit development of diabetes by increasing the proportion of CD4+Foxp3+ regulatory T cells in the islets in non-obese diabetic mice."],"weko_creator_id":"2","weko_shared_id":2},"updated":"2023-05-15T19:06:50.640208+00:00"}