{"created":"2023-05-15T16:42:07.773380+00:00","id":17011,"links":{},"metadata":{"_buckets":{"deposit":"06ff11e8-56ed-4329-a717-f9ef4cab59d6"},"_deposit":{"created_by":2,"id":"17011","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"17011"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00017011","sets":["29:30"]},"author_link":["66026","66019","66021","66018","66022","66025","66023","66020","66024","66017"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"257","bibliographicPageStart":"245","bibliographicVolumeNumber":"153","bibliographic_titles":[{"bibliographic_title":"Clinical and experimental immunology"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The deposition of immune complexes (IC) induces an acute inflammatory response with tissue injury, for which the involvement of nitric oxide (NO) and carbon monoxide (CO) has been suggested. NO is induced by NO synthase (NOS) and CO is generated by haeme oxygenase (HO). Among HO isoenzymes, HO-1 is an induced type. To assess the role of NO and CO in the pathogenic process, the cutaneous reverse passive Arthus reaction was examined using NOS inhibitor, HO-1 stimulator and HO-1 inhibitor. To evaluate the reaction we considered oedema, tumour necrosis factor-alpha, interleukin-6, and neutrophil number. The values of these four parameters were significantly reduced in mice treated with HO-1 stimulator as compared with the positive control mice. Quite the reverse was observed in mice treated with HO-1 inhibitor. These results suggest that the HO-1/CO signalling pathway is a therapeutic target for human IC-mediated disease.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Clinical and experimental immunology, 153(2), pp.245-257; 2008","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Blackwell Publishing Inc."}]},"item_2_relation_11":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"18505425","subitem_relation_type_select":"PMID"}}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1111/j.1365-2249.2008.03688.x","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Journal Compilation c 2008 British Society for Immunology"},{"subitem_rights":"The definitive version is available at www.blackwell-synergy.com"}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00607716","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00099104","subitem_source_identifier_type":"ISSN"}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"1365-2249","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Shimizu, Kazuhiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Bae, S J"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hara, Takeshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Iwata, Y"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamaoka, T"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Komura, Kazuhiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Muroi, Eiji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takenaka, Motoi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ogawa, Fumihide"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sato, Shinichi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-23"}],"displaytype":"detail","filename":"CEI153_245.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"CEI153_245.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/17011/files/CEI153_245.pdf"},"version_id":"328085b1-a0d6-4528-bb66-869685f57fe6"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Arthus reaction","subitem_subject_scheme":"Other"},{"subitem_subject":"Carbon monoxide","subitem_subject_scheme":"Other"},{"subitem_subject":"Haeme oxygenase-1","subitem_subject_scheme":"Other"},{"subitem_subject":"Nitric oxide","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Involvement of gaseous low molecular monoxides in the cutaneous reverse passive Arthus reaction: cytoprotective action of carbon monoxide.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Involvement of gaseous low molecular monoxides in the cutaneous reverse passive Arthus reaction: cytoprotective action of carbon monoxide."}]},"item_type_id":"2","owner":"2","path":["30"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-02-05"},"publish_date":"2010-02-05","publish_status":"0","recid":"17011","relation_version_is_last":true,"title":["Involvement of gaseous low molecular monoxides in the cutaneous reverse passive Arthus reaction: cytoprotective action of carbon monoxide."],"weko_creator_id":"2","weko_shared_id":2},"updated":"2023-05-15T19:05:29.817229+00:00"}