{"created":"2023-05-15T16:42:07.815340+00:00","id":17012,"links":{},"metadata":{"_buckets":{"deposit":"5ccde773-c43f-4611-8303-89b34748e09d"},"_deposit":{"created_by":2,"id":"17012","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"17012"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00017012","sets":["8:9"]},"author_link":["66033","66030","66027","66028","66036","66032","66034","66031","66029","66035"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-12","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"251","bibliographicPageStart":"248","bibliographicVolumeNumber":"1150","bibliographic_titles":[{"bibliographic_title":"Annals of the New York Academy of Sciences"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"In this study, we evaluated autoantibodies to IA-2 (IA-2As), glutamic acid decarboxylase 65 (GADAs), and islet cell antibodies (ICAs) in 233 patients with type 1 diabetes (M:F = 90:143, mean duration 4.0 +/- 6.7 yr) as a cross-sectional study. Of 233 patients with type 1 diabetes, IA-2A was detected in 58% of patients with duration within 2 weeks, 61% of patients with duration <1 yr, 41% of patients with diabetes for 1-3 yr, 29% for 4-9 yr, and 21% for >or=10 yr. These prevalences were similar to those of ICA, while the prevalence of GADA was not influenced by duration of diabetes with positivity of 63-74%. Thus, as the duration of diabetes became longer, the frequency of GADA(+)/IA-2A(-) patients increased and the frequency of GADA(+)/IA-2A(+) patients decreased. However, the frequency of GADA(-)/IA-2A(+) patients was not influenced by duration of diabetes. The prevalence of IA-2A was significantly higher in abrupt-onset group (68%, n= 79) compared to the slowly progressive group (23%, n= 22) in new-onset patients (P= 0.0001). However, there was no difference in the IA-2A frequency between these two groups (abrupt-onset 26%, n= 53 vs. slowly progressive 24%, n= 21) in patients with long-standing disease, suggesting that IA-2A positivity might persist in patients with slowly progressive type 1 diabetes. These results emphasize the heterogeneity of humoral autoimmunity to protein tyrosine phosphatase-like molecules, but not to GAD, in patients with type 1 diabetes.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Annals of the New York Academy of Sciences, 1150, pp.248-251; 2008","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"New York Academy of Sciences"}]},"item_2_relation_11":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"19120305","subitem_relation_type_select":"PMID"}}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1196/annals.1447.027","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c 2008 The New York Academy of Sciences"}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00051776","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00778923","subitem_source_identifier_type":"ISSN"}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"1749-6632","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kawasaki, Eiji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kuriya, Genpei"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Satoh, Tsuyoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fujishima, Keiichiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Moriuchi, Akie"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fukushima, Keiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ozaki, Masako"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Abiru, Norio"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamasaki, Hironori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Eguchi, Katsumi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-23"}],"displaytype":"detail","filename":"ANYAS1150_248.pdf","filesize":[{"value":"274.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ANYAS1150_248.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/17012/files/ANYAS1150_248.pdf"},"version_id":"92dce045-0b95-49c6-8f47-7f00228183d1"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"GAD","subitem_subject_scheme":"Other"},{"subitem_subject":"IA-2","subitem_subject_scheme":"Other"},{"subitem_subject":"ICA","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Humoral immune response to islet autoantigens in Japanese patients with type 1 diabetes.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Humoral immune response to islet autoantigens in Japanese patients with type 1 diabetes."}]},"item_type_id":"2","owner":"2","path":["9"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-02-05"},"publish_date":"2010-02-05","publish_status":"0","recid":"17012","relation_version_is_last":true,"title":["Humoral immune response to islet autoantigens in Japanese patients with type 1 diabetes."],"weko_creator_id":"2","weko_shared_id":2},"updated":"2023-05-15T19:24:37.661880+00:00"}