@article{oai:nagasaki-u.repo.nii.ac.jp:00017036,
 author = {Nishiyori, Michiko and Ueda, Hiroshi},
 journal = {Molecular pain},
 month = {Nov},
 note = {In a new mouse model for generalized pain syndrome, including fibromyalgia, which used intermittent cold stress (ICS), bilateral allodynia in the hindpaw was observed that lasted more than 12 days; thermal hyperalgesia lasted 15 days. During constant cold stress (CCS), mice showed only a transient allodynia. A female prevalence in ICS-induced allodynia was observed in gonadectomized but not in gonad intact mice. Systemic gabapentin showed complete anti-allodynic effects in the ICS model at the one-tenth dose for injury-induced neuropathic pain model, and central gabapentin showed long-lasting analgesia for 4 days in ICS, but not the injury model. These results suggest that the ICS model is useful for the study of generalized pain syndrome., Molecular Pain, 4, 52; 2008},
 title = {Prolonged gabapentin analgesia in an experimental mouse model of fibromyalgia.},
 volume = {4},
 year = {2008}
}