@article{oai:nagasaki-u.repo.nii.ac.jp:00017066,
 author = {Matsuu-Matsuyama, Mutsumi and Shichiji, Kazuko and Okaichi, Kumio and Nakayama, Toshiyuki and Nakashima, Masahiro and Uemura, Takashi and Niino, Daisuke and Sekine, Ichiro},
 issue = {4},
 journal = {Journal of Radiation Research},
 month = {Jul},
 note = {Polaprezinc, an anti-ulcer drug, is a chelate compound consisting of zinc and L-carnosine. Polaprezinc has been shown to prevent gastric mucosal injury. The anti ulcer effects of polaprezinc have been ascribed to its antioxidative property. The effect of polaprezinc on ionizing radiation-induced apoptosis was studied in the jejunal epithelial crypt cells of rats. Seven-to eight week-old Wistar rats, which were treated with 100 mg/kg of polaprezinc orally 1h before irradiation or 2% carboxymethyl cellulose sodium in controls, were exposed to whole body X-ray irradiation at 2 Gy. The number of apoptotic cells per jejunum crypt was counted in haematoxylin and eosin stained sections at 0-6 h after irradiation. TUNEL positive cells and immunopositive cells for active caspase-3 per crypt were also counted. Accumulation of p53, p21^<WAF1/CIP1> and Bax expression in the jejunum after irradiation were examined by Western blot analyses. Polaprezinc treatment given prior to radiation resulted in a significant reduction in numbers of apoptotic cells, TUNEL positive cells and active caspase-3 immunopositive cells in jejunal crypt cells. Polaprezinc treatment resulted in decreases of p53 accumulation, p21^<WAF1/CIP1> and Bax expression after irradiation. Polaprezinc has a protective effect against ionizing radiation induced apoptosis in rat jejunal crypt cells., Journal of Radiation Research, 49(4), pp.341-347; 2008},
 pages = {341--347},
 title = {Protection by Polaprezinc Against Radiation-Induced Apoptosis in Rat Jejunal Crypt Cells},
 volume = {49},
 year = {2008}
}