{"created":"2023-05-15T16:42:10.108390+00:00","id":17066,"links":{},"metadata":{"_buckets":{"deposit":"99bc92d1-084c-40d5-b10f-17f977e90f7f"},"_deposit":{"created_by":2,"id":"17066","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"17066"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00017066","sets":["25:26"]},"author_link":["66346","66350","66347","66348","66345","66349","66351","66352"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-07","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"347","bibliographicPageStart":"341","bibliographicVolumeNumber":"49","bibliographic_titles":[{"bibliographic_title":"Journal of Radiation Research"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Polaprezinc, an anti-ulcer drug, is a chelate compound consisting of zinc and L-carnosine. Polaprezinc has been shown to prevent gastric mucosal injury. The anti ulcer effects of polaprezinc have been ascribed to its antioxidative property. The effect of polaprezinc on ionizing radiation-induced apoptosis was studied in the jejunal epithelial crypt cells of rats. Seven-to eight week-old Wistar rats, which were treated with 100 mg/kg of polaprezinc orally 1h before irradiation or 2% carboxymethyl cellulose sodium in controls, were exposed to whole body X-ray irradiation at 2 Gy. The number of apoptotic cells per jejunum crypt was counted in haematoxylin and eosin stained sections at 0-6 h after irradiation. TUNEL positive cells and immunopositive cells for active caspase-3 per crypt were also counted. Accumulation of p53, p21^<WAF1/CIP1> and Bax expression in the jejunum after irradiation were examined by Western blot analyses. Polaprezinc treatment given prior to radiation resulted in a significant reduction in numbers of apoptotic cells, TUNEL positive cells and active caspase-3 immunopositive cells in jejunal crypt cells. Polaprezinc treatment resulted in decreases of p53 accumulation, p21^<WAF1/CIP1> and Bax expression after irradiation. Polaprezinc has a protective effect against ionizing radiation induced apoptosis in rat jejunal crypt cells.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Journal of Radiation Research, 49(4), pp.341-347; 2008","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本放射線影響学会"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1269/jrr.07114","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright (c) 2008 by THE JAPAN RADIATION RESEARCH SOCIETY"},{"subitem_rights":"本文データは学協会の許諾に基づきCiNiiから複製したものである"}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00705792","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"04493060","subitem_source_identifier_type":"ISSN"}]},"item_2_text_62":{"attribute_name":"出版者別言語","attribute_value_mlt":[{"subitem_text_value":"THE JAPAN RADIATION RESEARCH SOCIETY"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Matsuu-Matsuyama, Mutsumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shichiji, Kazuko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Okaichi, Kumio"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakayama, Toshiyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakashima, Masahiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Uemura, Takashi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Niino, Daisuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sekine, Ichiro"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-23"}],"displaytype":"detail","filename":"110006820173.pdf","filesize":[{"value":"1.6 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"110006820173.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/17066/files/110006820173.pdf"},"version_id":"b5ac1000-3e98-49e4-8875-73fa3efb2ee6"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Radiation-induced apoptosis","subitem_subject_scheme":"Other"},{"subitem_subject":"Polaprezinc","subitem_subject_scheme":"Other"},{"subitem_subject":"p53","subitem_subject_scheme":"Other"},{"subitem_subject":"Rats","subitem_subject_scheme":"Other"},{"subitem_subject":"Intestine","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Protection by Polaprezinc Against Radiation-Induced Apoptosis in Rat Jejunal Crypt Cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Protection by Polaprezinc Against Radiation-Induced Apoptosis in Rat Jejunal Crypt Cells"}]},"item_type_id":"2","owner":"2","path":["26"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-02-02"},"publish_date":"2009-02-02","publish_status":"0","recid":"17066","relation_version_is_last":true,"title":["Protection by Polaprezinc Against Radiation-Induced Apoptosis in Rat Jejunal Crypt Cells"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-17T20:27:01.300780+00:00"}