{"created":"2023-05-15T16:42:10.193905+00:00","id":17068,"links":{},"metadata":{"_buckets":{"deposit":"491e0401-a603-4450-9023-d935d008a0d1"},"_deposit":{"created_by":2,"id":"17068","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"17068"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00017068","sets":["25:26"]},"author_link":["66358","66356","66360","66354","66361","66357","66359","66362","66355"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"27","bibliographicPageStart":"17","bibliographicVolumeNumber":"49","bibliographic_titles":[{"bibliographic_title":"Journal of Radiation Research"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Thyroid hormone receptors (THRs) widely govern cell growth, differentiation and metabolism acting in a ligand- and cofactor-dependent manner to modulate tissue-specific gene expression. Given a large variety of genes regulated by THRs and multiplicity of cellular processes potentially influenced by THRs, we addressed the role of THRB (thyroid hormone receptor beta) in cellular radiosensitivity. Wild-type and mutant THRB were overexpressed in several cell lines using an adenovirus-mediated gene delivery and their effects were examined after cell exposure to γ-rays. Wild-type THRB decreased clonogenic survival of the cell lines with low levels of endogenous THRB, retarded their growth and synergized with radiation in decreasing proliferative potential and promoting cellular senescence. These changes were accompanied by the accumulation of p21 (CDKN1A, CIP1, WAF1) and p16 (CDKN2A, INK4a) inhibitors of cyclindependent kinases and by the decrease of Rb (retinoblastoma protein) phosphorylation. Mutant THRB produced a radioprotective effect, attenuated radiation-induced growth inhibition and cellular senescence. The results suggest that THRB may modulate cellular radiosensitivity and stress-induced senescence.","subitem_description_type":"Abstract"}]},"item_2_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"長崎大学学位論文 学位記番号:博（医歯薬）甲第148号 博士（医学）学位授与年月日:平成20年3月19日","subitem_description_type":"Other"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Journal of Radiation Research, 49(1), pp.17-27; 2008","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本放射線影響学会"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1269/jrr.07065","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright (c) 2008 by THE JAPAN RADIATION RESEARCH SOCIETY"},{"subitem_rights":"本文データは学協会の許諾に基づきCiNiiから複製したものである"}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00705792","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"04493060","subitem_source_identifier_type":"ISSN"}]},"item_2_text_62":{"attribute_name":"出版者別言語","attribute_value_mlt":[{"subitem_text_value":"THE JAPAN RADIATION RESEARCH SOCIETY"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Matsuse, Michiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Saenko, Vladimir"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sedliarou, Ilya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Rogounovitch, Tatiana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakazawa, Yuka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mitsytake, Norisato"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Akulevich, Natallia"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Namba, Hiroyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamashita, Shunichi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-23"}],"displaytype":"detail","filename":"110006570524.pdf","filesize":[{"value":"2.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"110006570524.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/17068/files/110006570524.pdf"},"version_id":"b81e8a02-b875-44d7-932e-6099271ee361"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Thyroid hormone receptor beta","subitem_subject_scheme":"Other"},{"subitem_subject":"Radiosensitivity","subitem_subject_scheme":"Other"},{"subitem_subject":"Clonogenic survival","subitem_subject_scheme":"Other"},{"subitem_subject":"Cellular senescence","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"A Novel Role for Thyroid Hormone Receptor Beta in Cellular Radiosensitivity","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A Novel Role for Thyroid Hormone Receptor Beta in Cellular Radiosensitivity"}]},"item_type_id":"2","owner":"2","path":["26"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-02-02"},"publish_date":"2009-02-02","publish_status":"0","recid":"17068","relation_version_is_last":true,"title":["A Novel Role for Thyroid Hormone Receptor Beta in Cellular Radiosensitivity"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-17T20:26:55.272057+00:00"}