@article{oai:nagasaki-u.repo.nii.ac.jp:00017073,
 author = {Nanashima, Atsushi and Araki, M and Tobinaga, Syuichi and Kunizaki, Masaki and Hidaka, Shigekazu and Shibata, K and Mochinaga, Kouji and Sawai, T and Isomoto, Hajime and Ohnita, Ken and Uehara, M and Nagayasu, Takeshi},
 issue = {5},
 journal = {European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology},
 month = {Jan},
 note = {AIM: Cancer death in the early period after hepatectomy still occurs in patients with colorectal liver metastasis (CLM). We examined the relationship between clinicopathological parameters and survival periods in 130 CLM patients who underwent hepatectomy. PATIENTS/METHODS: Patients were divided into four groups: Group 1 (5-year survivors without tumor relapse), Group 2 (survivors at 2-5years), Group 3 (cancer death at 2-5years), and Group 4 (cancer death within 2years). RESULTS: A short surgical margin was frequent in Group 4 compared to Group 1 (31 vs. 78%, P<0.05). Primary node-positive status, absence of fibrous pseudo-capsular formation, higher Clinical Risk Score, and tumor recurrence within 12months were frequent in Group 4 (P<0.05). Multivariate analysis revealed a short surgical margin (HR; 3.5) and early tumor relapse (HR; 5.9) as independently significant related parameters (P<0.05). CONCLUSIONS: Sufficient surgical margins and careful follow-up for early tumor relapse may be important for improving postoperative outcomes for CLM patients., European Journal of Surgical Oncology, 35(5), pp.504-509; 2009},
 pages = {504--509},
 title = {Relationship between period of survival and clinicopathological characteristics in patients with colorectal liver metastasis},
 volume = {35},
 year = {2009}
}