@article{oai:nagasaki-u.repo.nii.ac.jp:00017208,
 author = {沖田, 実 and 吉村, 俊朗 and 田原, 弘幸 and 加藤, 克知 and 中野, 裕之 and 井口, 茂 and 中野, 治郎},
 issue = {1},
 journal = {理学療法学, The Journal of Japanese Physical Therapy Association},
 month = {Jan},
 note = {本研究は, 関節固定によるラットヒラメ筋の筋内膜コラーゲン線維網の構築への影響を検索し, 短縮筋の弾性低下の要因を検討した。実験動物はウイスター系雄ラット5匹で, 右足部を4週間ギプス固定し, ヒラメ筋の筋肉膜コラーゲン線維網を走査電子顕微鏡で検鏡した。また, 筋縦断面を光学および透過電子顕微鏡で検鏡した。固定側の筋内膜コラーゲン細線維は有意に肥大し, その構築は筋線維長軸に対して横走していた。さらに, 固定側の筋節長は有意に短縮していた。このことから, 短縮筋の弾性低下には筋内膜コラーゲン細線維の分子間架橋結合に加えて, その構築的変化が影響していることが示唆された。, One of the main properties of skeletal muscles is elastic behaviour, which is related to the intramuscular collagen fibrillar arrangement. In general, immobilized muscle shows decreased elasticity, but it is not known how changes in elasticity affect the collagen fibrillar arrangement. We therefore examined the collagen fibrillar arrangements in the endomysium of the soleus muscles after immobilization of ankle joint of the rat. Five male wistar rats (age 18-22 weeks, weight 350-460g) were used in this study. Right ankle of the rat was immobilized in planter-flexed position using plaster cast. After four weeks, the soleus muscles were biopsied. Muscles were stretched with a 4g sinker, and fixed in 3% glutaraldehyde. According to the cell-maceration method, muscle samples were immersed in a 10% aqueous solution of sodium hydroxide, and then rinsed in distilled water at room temperature. The specimens were observed using a scanning electron microscope. Other muscle samples embedded in Epon, and blocks of muscle tissue were sectioned logitudinally. The sections were observed with a light microscope and an electron microscope. As a result; The collagen fibrilles in the endomysium after immobilization were hypertrophic, and the transverse component of collagen fibrilles was increased. The sarcomere lengths after immobilization were decreased. We presume that hypertrophy of the collagen fibrilles after immobilization is affected by intermolecular cross-links, and that an increased transverse component of collagen fibrilles might affect the series elastic component of immobilized soleus muscle., 理学療法学. 24(1), p.23-30: 1997},
 pages = {23--30},
 title = {関節固定がラットヒラメ筋の筋内膜コラーゲン線維網の構築におよぼす影響},
 volume = {24},
 year = {1997}
}