@article{oai:nagasaki-u.repo.nii.ac.jp:00017226,
 author = {中野, 治郎 and 沖田, 実 and 吉村, 俊郎 and 東, 登志夫 and 加藤, 克知 and 田原, 弘幸 and 大木田, 治夫 and 辻畑, 光宏},
 issue = {2},
 journal = {理学療法学, The Journal of Japanese Physical Therapy Association},
 month = {Mar},
 note = {今回われわれは, 筋ジストロフィーの実験動物モデルであるmdxマウスを用い, 等尺性収縮運動が筋線維におよぼす影響を形態学的, 病理学的所見から検討した。8週齢の雄のmdxマウスを用い, 5匹ずつ運動群と非運動群に分け, 対照として同週齢のC57 BL/ 10scn雄マウスを同様に2群に分けた。等尺性収縮による運動負荷は1日1回10分間, 週5回, 4週間実施した。結果, 長距伸筋において, mdxマウス・対照マウス両者とも運動群に筋肥大が認められた。また, mdxマウスの運動群では小径線維並びにfiber splittingの割合が少なかった。したがって等尺性収縮運動は筋肥大をもたらし, また筋病変の進行を抑制する可能性が示唆された。, The effects of isometric contraction on muscle fibers were investigated from morphological and pathological aspects using mdx mouse, an animal model of muscular dystrophy. Ten male mdx mice at 8 weeks of age were divided into 2 groups: one group was loaded with an exercise of isometric contraction and the other was not loaded. As the control, male mice of C57BL/10ScN at the same age were similarly assigned into the two groups. The loading of isometric contraction was carried out 5 times per week for daily 10 min during a period of 4 weeks, A significant thickening of the long extensor muscle of digits was observed in both loaded groups of mdx mice and control.In addition, the proportion of fibers having a small diameter and the degree of fiber splltting were smaller in the loaded group of mdx mice. These results suggest that isometric contraction might result in muscular thickening and repress the progressing of myopathy., 理学療法学. 25(2), p.86-92: 1998},
 pages = {86--92},
 title = {mdxマウスの後肢筋群に対する等尺性収縮運動の影響},
 volume = {25},
 year = {1998}
}