{"created":"2023-05-15T16:42:18.594361+00:00","id":17263,"links":{},"metadata":{"_buckets":{"deposit":"57d8303a-7c97-4f40-b7e2-b51a2c40d2d1"},"_deposit":{"created_by":2,"id":"17263","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"17263"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00017263","sets":["29:30"]},"author_link":["67504","67513","67505","67512","67510","67507","67511","67508","67509","67506"],"item_2_alternative_title_19":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Effects of Isometric Exercise on Disuse Muscle Atrophy in Mdx Mice"}]},"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2000-07-31","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"156","bibliographicPageStart":"151","bibliographicVolumeNumber":"27","bibliographic_titles":[{"bibliographic_title":"理学療法学"},{"bibliographic_title":"The Journal of Japanese Physical Therapy Association","bibliographic_titleLang":"en"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"進行した廃用性筋萎縮を伴うジストロフィー筋に対する等尺性収縮運動の影響を組織病理学的に検討した。実験動物にはmdx雄マウス20匹を用い, 対照群(n=5)と実験群(n=15)に振り分けた。実験群には後肢懸垂を2週間実施し, 廃用性筋萎縮を惹起させた。そして実験群の内5匹は後肢懸垂のみとし, 5匹は後肢懸垂後に通常飼育を2週間, 他の5匹は後肢懸垂後に体重の50%の重錘を尾部につけて行う等尺性収縮運動を2週間負荷した。結果, 長趾伸筋では運動負荷による筋線維の肥大効果を認めず, 病理学的所見の出現頻度も助長されなかった。一方, ヒラメ筋においては筋線維の肥大効果が認められたが, 筋線維壊死も増加していた。これらのことから, 廃用性筋萎縮が進行したジストロフィー筋に対する等尺性収縮運動は, 筋線維肥大をもたらす有効なものであるが, 一部の筋線維に対しては筋損傷といった悪影響をおよぼす可能性があると推察された。","subitem_description_type":"Abstract"},{"subitem_description":"There are some reports on the effect of prevention by exercise for atrophic muscle fiber in model mice of dystrophy. However, it is still unclear how much exercise would be beneficial for the atrophic muscle fibers in muscular dystrophy. We therefore studied the effect of isometric exercise on atrophic muscles in mdx mice after hindlimb suspension(HS). Twenty male mdx mice were used and divided randomly into four groups : control, HS only(mHS), non-exercise for 2 weeks after HS(mHS-NE), and isometric exercise with a load weight after HS (mHS-E). HS was carried out for 2 weeks. The isometric exercise was done with stationary support on a grid at 80゜, equal to 50% of body weight attached to the tail for 10 min/day, 5 days/week for 2 weeks. We obtained extensor digitorum longus(EDL)and soleus(SOL)muscles followed by a section stained with hematoxylin-eosin. Quantitative assessment of the muscles include the diameter of muscle fibers, the rate of necrotic fibers, the internal nuclei fibers and splitting fibers. The fiber diameter of both muscles in the mHS-NE and mHS-E groups showed significant hypertrophy compared with the mHS group. And the fiber diameter of the SOL in the mHS-E group had significant hypertrophy compared to other groups. While there was no significant difference in the mean muscle fiber diameter of the EDL between the mHS-NE group and mHS-E group, the isometric exercise didn't induce necrotic fibers, internal nuclei fibers and the splitting of the EDL. In the SOL, however, the rate of internal nuclei fibers in the mHS-E group increased compared with the mHS-NE group. We found that exercise for the atrophic muscle fibers in muscular dystrophy could bring about muscle fiber hypertrophy, but it is possible that exercise could promote the necrosis of any muscle fibers.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"理学療法学. 27(5), p.151-156: 2000","subitem_description_type":"Other"}]},"item_2_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"67509","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Nakano, Jiro"}]},{"nameIdentifiers":[{"nameIdentifier":"67510","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Okita, Minoru"}]},{"nameIdentifiers":[{"nameIdentifier":"67511","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Yoshimura, Toshiro"}]},{"nameIdentifiers":[{"nameIdentifier":"67512","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Tsujihata, Mitsuhiro"}]},{"nameIdentifiers":[{"nameIdentifier":"67513","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Ohkida, Haruo"}]}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"社団法人日本理学療法士協会"}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"社団法人日本理学療法士協会"},{"subitem_rights":"本文データは学協会の許諾に基づきCiNiiから複製したものである"}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN10146032","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"02893770","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"中野, 治郎"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"沖田, 実"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"吉村, 俊朗"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"辻畑, 光宏"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"大木田, 治夫"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-23"}],"displaytype":"detail","filename":"rigaku27_5_151_156.pdf","filesize":[{"value":"811.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"rigaku27_5_151_156.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/17263/files/rigaku27_5_151_156.pdf"},"version_id":"446434ac-874e-4996-861d-8dcd450aae40"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ジストロフィー筋","subitem_subject_scheme":"Other"},{"subitem_subject":"廃用性筋萎縮","subitem_subject_scheme":"Other"},{"subitem_subject":"等尺性収縮運動","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"筋ジストロフィーモデルマウスにおける廃用性筋萎縮に対する等尺性収縮運動の影響","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"筋ジストロフィーモデルマウスにおける廃用性筋萎縮に対する等尺性収縮運動の影響"}]},"item_type_id":"2","owner":"2","path":["30"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-03-05"},"publish_date":"2009-03-05","publish_status":"0","recid":"17263","relation_version_is_last":true,"title":["筋ジストロフィーモデルマウスにおける廃用性筋萎縮に対する等尺性収縮運動の影響"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-17T20:18:42.353567+00:00"}