{"created":"2023-05-15T16:42:34.587198+00:00","id":17636,"links":{},"metadata":{"_buckets":{"deposit":"c7f79ebf-0e4d-4ca7-be5b-b0b890638939"},"_deposit":{"created_by":2,"id":"17636","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"17636"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00017636","sets":["29:30:1713167819629:1328"]},"author_link":["69624","69625","69626","69623","69627"],"item_3_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"64","bibliographicPageStart":"59","bibliographicVolumeNumber":"53","bibliographic_titles":[{"bibliographic_title":"Acta medica Nagasakiensia"}]}]},"item_3_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Gamma-tocopherol is largely metabolized to 2,7,8-trimethyl-2-(2'-carboxyethyl)-6-hydroxychroman (γ-CEHC), which has natriuretic activity that is mediated via inhibition of 70 pS ATP-sensitive K+ channels in the thick ascending limb of the loop of Henle. However, the effects of γ-tocopherol administration on edema are unclear. To determine the effects of γ-tocopherol administration on pretibial edema, we measured urinary γ-CEHC concentration by high-performance liquid chromatography with electrochemical detection (HPLC-ECD) after administration of γ-tocopherol. Twenty young women who had a history of pretibial edema due to premenstrual syndrome were randomly divided into two groups. The γ-tocopherol group received 4 \"γ-tocopherol capsules\" (each containing 100mg of γ-tocopherol), and the control group received 4 \"placebo capsules\" (each containing 250mg of soybean oil) per day for 7 days. Urinary sodium and potassium secretion and urine volume did not increase after cessation of γ-tocopherol administration, yet the degree of pretibial edema improved in all participants in the γ-tocopherol group. The serum γ-tocopherol concentration significantly increased in the γ-tocopherol group. Urinary excretion of γ-CEHC significantly increased after γ-tocopherol administration. Our results suggest that orally administered γ-tocopherol on renal sodium handling is not apparent, but γ-tocopherol is a precursor of prolonged natriuresis of γ-CEHC and may be effective for edema.","subitem_description_type":"Abstract"}]},"item_3_description_64":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Acta medica Nagasakiensia, 53(3), pp.59-64 ; 2009","subitem_description_type":"Other"}]},"item_3_relation_42":{"attribute_name":"関係URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://joi.jlc.jst.go.jp/JST.JSTAGE/amn/53.59"}]}]},"item_3_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00508430","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00016055","subitem_source_identifier_type":"ISSN"}]},"item_3_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kato, Shigeko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shiraishi, Keiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Koshida, Sayo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mune, Masatoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Omagari, Katsuhisa"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-23"}],"displaytype":"detail","filename":"acta_53_3_59.pdf","filesize":[{"value":"444.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"acta_53_3_59.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/17636/files/acta_53_3_59.pdf"},"version_id":"de5deb1b-feac-45d6-ba24-ef5119f4708c"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"γ-tocopherol","subitem_subject_scheme":"Other"},{"subitem_subject":"γ-CEHC","subitem_subject_scheme":"Other"},{"subitem_subject":"Premenstrual syndrome","subitem_subject_scheme":"Other"},{"subitem_subject":"Edema","subitem_subject_scheme":"Other"},{"subitem_subject":"HPLC","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"The Effects of γ-tocopherol Administration on Pretibial Edema in Young Women with Premenstrual Syndrome","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The Effects of γ-tocopherol Administration on Pretibial Edema in Young Women with Premenstrual Syndrome"}]},"item_type_id":"3","owner":"2","path":["1328"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-04-07"},"publish_date":"2009-04-07","publish_status":"0","recid":"17636","relation_version_is_last":true,"title":["The Effects of γ-tocopherol Administration on Pretibial Edema in Young Women with Premenstrual Syndrome"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2024-04-16T05:33:31.089428+00:00"}