@article{oai:nagasaki-u.repo.nii.ac.jp:00017660,
 author = {Osawa, Hikota and Troye-Blomberg, Marita and Hirayama, Kenji and Kikuchi, Mihoko and Hombhanje, Francis and Tanihata, Takeo and Udomsangpetch, Rachanee and Björkman, Anders and Kobayakawa, Takatoshi and Kaneko, Akira},
 issue = {2},
 journal = {Tropical medicine and health},
 month = {Jun},
 note = {In malaria endemic areas, people naturally acquire an age-related immunity to malaria. Part of this immunity involves anti-malarial specific antibodies. Acquisition of these malaria-specific antibodies depends not only on exposure to malaria parasites but also on the human genetic predisposition. CTLA-4 is a costimulatory molecule that delivers an inhibitory signal to suppress T-cell as well as B-cell responses. We investigated associations between malaria-specific antibody levels and CTLA-4 polymorphisms in 189 subjects living in a hyper-endemic area of Papua New Guinea (PNG), where both P. falciparum and P. vivax are prevalent. We determined P. falciparum/ P. vivax specific IgG/IgE levels (Pf-IgG, Pv-IgG, Pf-IgE, Pv-IgE) and polymorphisms in the CTLA-4 gene at position -1661 promoter region (A/G), the +49 exon 1 non-synonymous mutation (A/G), and the +6230 3‘-UTR (A/G). All quantified antibody levels were significantly higher in subjects > 5 years (n = 150) than in subjects 5 years of age (n = 39). In children 5 years old, significant associations were detected between CTLA-4 +49 (GG/AG vs. AA) and Pv-IgG (median 18.7 vs. 13.7 Μg/ml, P = 0.017) and Pv-IgE (266.6 vs. 146.5 pg/ml, P = 0.046). No significant difference was observed in subjects > 5 years old. These results suggest that the CTLA-4+49 polymorphism influenced Pv-IgG and Pv-IgE levels among children less than five years old in the studied population, which may regulate the age- and species-specific clinical outcomes of malaria infection., Tropical Medicine and Health Vol. 36 No. 2, 2008, pp. 93-100},
 pages = {93--100},
 title = {CTLA-4 polymorphisms and anti-malarial antibodies in a hyper-endemic population of Papua New Guinea},
 volume = {36},
 year = {2008}
}