{"created":"2023-05-15T16:42:40.023716+00:00","id":17761,"links":{},"metadata":{"_buckets":{"deposit":"e2d6da10-6170-4951-a069-3fe653f02bfa"},"_deposit":{"created_by":2,"id":"17761","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"17761"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00017761","sets":["29:30:1713167819629:1330"]},"author_link":["70182","70181","70178","70184","70183","70179","70180"],"item_3_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"88","bibliographicPageStart":"85","bibliographicVolumeNumber":"53","bibliographic_titles":[{"bibliographic_title":"Acta medica Nagasakiensia"}]}]},"item_3_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"AIM: The aim of this study was to investigate the role for vascular endothelial growth factor (VEGF) and its receptors, VEGFR-1 and -2, in the hyperplastic polyp (HP)- serrated adenoma (SA)-adenocarcinoma (AC) sequence of the colorectum.Methods: Thirty-six HPs, 33 SAs and 7 ACs (which contained HP and/or SA) were immunohistochemically examined for the expression of VEGF, VEGFR-1, and VEGFR-2.Results: VEGF protein was expressed in the cytoplasm of SA and AC tumor cells, and VEGFR-1 and VEGFR-2 were expressed both in the cytoplasm and on the membrane of these tumors, while there was faint or no expression of VEGF, VEGFR-1 and VEGFR-2 in HPs. Immunohistochemical staining revealed that 8.3% (3 of 36) HPs, 87.9% (29 of 33) SAs and 100% (7 of 7) ACs were positive for VEGF; 2.8% (1 of 36) HPs, 97.0% (32 of 33) SAs and 100% (7 of 7) ACs were positive for VEGFR-1; 16.7% (6 of 36) HPs, 100% (33 of 33) SAs and 100% (7 of 7) ACs were positive for VEGFR-2. The expression of VEGF, VEGFR-1 or VEGFR-2 was statistically correlated with the sequence of HP, SA and AC (P < 0.0001, respectively) Conclusion: Our results suggest that the VEGF pathway may play an important role in the HP-SA-AC sequence.","subitem_description_type":"Abstract"}]},"item_3_description_64":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Acta medica Nagasakiensia, 53(4), pp.85-88 ; 2009","subitem_description_type":"Other"}]},"item_3_relation_42":{"attribute_name":"関係URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://joi.jlc.jst.go.jp/JST.JSTAGE/amn/53.85"}]}]},"item_3_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00508430","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00016055","subitem_source_identifier_type":"ISSN"}]},"item_3_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Taba, Mitsuru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakayama, Toshiyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Naito, Shinji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mihara, Yumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miura, Shiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Naruke, Yuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sekine, Ichiro"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-23"}],"displaytype":"detail","filename":"acta_53_4_85.pdf","filesize":[{"value":"233.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"acta_53_4_85.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/17761/files/acta_53_4_85.pdf"},"version_id":"eaa02e68-f27e-42b1-96fb-7d81965518de"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"VEGF","subitem_subject_scheme":"Other"},{"subitem_subject":"VEGF receptor","subitem_subject_scheme":"Other"},{"subitem_subject":"Hyperplastic polyp","subitem_subject_scheme":"Other"},{"subitem_subject":"Serrated adenoma","subitem_subject_scheme":"Other"},{"subitem_subject":"Adenocarcinoma","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Differential Expression of Vascular Endothelial Growth Factor (VEGF) and VEGF Receptors in the Sequence of Hyperplastic Polyp, Serrated Adenoma and Adenocarcinoma of Colorectum","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Differential Expression of Vascular Endothelial Growth Factor (VEGF) and VEGF Receptors in the Sequence of Hyperplastic Polyp, Serrated Adenoma and Adenocarcinoma of Colorectum"}]},"item_type_id":"3","owner":"2","path":["1330"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-04-22"},"publish_date":"2009-04-22","publish_status":"0","recid":"17761","relation_version_is_last":true,"title":["Differential Expression of Vascular Endothelial Growth Factor (VEGF) and VEGF Receptors in the Sequence of Hyperplastic Polyp, Serrated Adenoma and Adenocarcinoma of Colorectum"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2024-04-16T05:33:13.781050+00:00"}