@article{oai:nagasaki-u.repo.nii.ac.jp:00017927,
 author = {Suzuki, Masatoshi and Suzuki, Keiji and Yamashita, Shunichi},
 issue = {supl.},
 journal = {Acta medica Nagasakiensia},
 month = {Mar},
 note = {The microenvironment is consisted both of soluble factors involving growth factors and of insoluble factors. Stroma cells contribute to form the microenvironment through a secretion of these factors. Fibroblast, which is known as stroma cells, also secretes various soluble/ insoluble factors, but the secretion level is significantly up-regulated when they reach to a finite replicative lifespan. Recent accumulating studies not only in vitro but also in vivo provide us that secreted proteins from senescent cells promote pro-survival pathway in bystander cells, especially tumor cells rather than normal cells. Since various stresses including ionizing radiation (IR) prematurely induces cellular senescent stage, called Stress-Induced Premature Senescence (SIPS), there is the possibility that the secretion pathway in cells undergoing SIPS is also activated. Here, we propose that pro-survival factor is secreted from SIPS cells to provide the stress-resistant microenvironment., Acta medica Nagasakiensia, 53(supl.), pp.51-53 ; 2009},
 pages = {51--53},
 title = {A Possible Role of Stress-Induced Premature Senescence, SIPS, as a Producer of the Stress-Resistant Microenvironment},
 volume = {53},
 year = {2009}
}