{"created":"2023-05-15T16:42:47.076989+00:00","id":17927,"links":{},"metadata":{"_buckets":{"deposit":"d9570039-bcb5-493a-8d2f-710c2965a1b9"},"_deposit":{"created_by":2,"id":"17927","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"17927"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00017927","sets":["29:30:1713167819629:1331"]},"author_link":["71047","71048","71049"],"item_3_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"supl.","bibliographicPageEnd":"53","bibliographicPageStart":"51","bibliographicVolumeNumber":"53","bibliographic_titles":[{"bibliographic_title":"Acta medica Nagasakiensia"}]}]},"item_3_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The microenvironment is consisted both of soluble factors involving growth factors and of insoluble factors. Stroma cells contribute to form the microenvironment through a secretion of these factors. Fibroblast, which is known as stroma cells, also secretes various soluble/ insoluble factors, but the secretion level is significantly up-regulated when they reach to a finite replicative lifespan. Recent accumulating studies not only in vitro but also in vivo provide us that secreted proteins from senescent cells promote pro-survival pathway in bystander cells, especially tumor cells rather than normal cells. Since various stresses including ionizing radiation (IR) prematurely induces cellular senescent stage, called Stress-Induced Premature Senescence (SIPS), there is the possibility that the secretion pathway in cells undergoing SIPS is also activated. Here, we propose that pro-survival factor is secreted from SIPS cells to provide the stress-resistant microenvironment.","subitem_description_type":"Abstract"}]},"item_3_description_64":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Acta medica Nagasakiensia, 53(supl.), pp.51-53 ; 2009","subitem_description_type":"Other"}]},"item_3_relation_42":{"attribute_name":"関係URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://joi.jlc.jst.go.jp/JST.JSTAGE/amn/53.S45"}]}]},"item_3_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00508430","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00016055","subitem_source_identifier_type":"ISSN"}]},"item_3_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Suzuki, Masatoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Suzuki, Keiji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamashita, Shunichi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-23"}],"displaytype":"detail","filename":"acta_53_supl_51.pdf","filesize":[{"value":"75.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"acta_53_supl_51.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/17927/files/acta_53_supl_51.pdf"},"version_id":"0473605e-c5b5-4a65-aaf8-ed1329edc920"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Stress-induced premature senescence","subitem_subject_scheme":"Other"},{"subitem_subject":"Replicative senescence","subitem_subject_scheme":"Other"},{"subitem_subject":"Secretion factor","subitem_subject_scheme":"Other"},{"subitem_subject":"Stress-resistant microenvironment","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"A Possible Role of Stress-Induced Premature Senescence, SIPS, as a Producer of the Stress-Resistant Microenvironment","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A Possible Role of Stress-Induced Premature Senescence, SIPS, as a Producer of the Stress-Resistant Microenvironment"}]},"item_type_id":"3","owner":"2","path":["1331"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-05-01"},"publish_date":"2009-05-01","publish_status":"0","recid":"17927","relation_version_is_last":true,"title":["A Possible Role of Stress-Induced Premature Senescence, SIPS, as a Producer of the Stress-Resistant Microenvironment"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2024-04-16T05:32:54.117438+00:00"}