| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2008-08-12 |
| タイトル |
|
|
タイトル |
Effects of Protein Kinase Inhibitors on the Accumulation Kinetics of p53 Protein in Normal Human Embryo Cells following X-irradiation |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Quercetin |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Calphostin-c |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Wortmannin |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
p53 |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
X-rays |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Ghosh, Jagadish Chandra
Suzuki, Keiji
Kodama, Seiji
Watanabe, Masami
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
DNA-damaging agents induce phosphorylation of the p53 protein, resulting in its accumulation in the nucleus. To clarify the signal transduction pathway(s) involved in p53 protein accumulation in normal human embryo cells following X-irradiation, the effects of three protein kinase inhibitors were examined. Quercetin, an inhibitor of heat-shock response, dose dependently suppressed the p53 accumulation induced by X-rays at more than 100μM. No suppression, however, was observed with calphostin-C, a specific inhibitor of protein kinase C, in the range of 0.05 to 0.25μM. Wortmannin was the most potent inhibitor of p53 accumulation. Its suppressive effect appears within a few minutes of pretreatment with a dose of 25μM, but posttreatment was less effective. Our findings suggest that PKC is not involved in X-ray-induced p53 accumulation in normal human embryo cells and that a wortmannin-sensitive pathway acts as a sensor of DNA damage. |
| 書誌情報 |
Journal of radiation research
巻 40,
号 1,
p. 23-37,
発行日 1999-03
|
| 出版者 |
|
|
出版者 |
日本放射線影響学会 |
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
04493060 |
| 書誌レコードID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00705792 |
| 権利 |
|
|
権利情報 |
日本放射線影響学会 |
| 権利 |
|
|
権利情報 |
本文データは学協会の許諾に基づきCiNiiから複製したものである |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 引用 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Journal of radiation research. 1999, 40(1), p.23-37 |
RR40_1_23_37.pdf (185.4 kB)
